How Piramidal Is Using AI to Decode the Human Brainhttps://venturebeat.com/ai/exclusive-how-piramidal-is-using-ai-to-decode-the-human-brain/The human brain is ultimately one of the last frontiers — a paradoxical black box that we can’t even begin to understand ourselves.
But what if, just as paradoxically, AI could interpret the complexities of the brain to help identify and diagnose some of our most serious diseases?
That’s exactly what Y Combinator-backed startup
Piramidal has set out to do.
The company is building a first-of-its-kind foundation model that can detect and understand complex “brain language” or brainwaves. It can be fine-tuned to a range of electroencephalography (EEG) use cases, and has implications in other areas of medicine, as well as in pharmacology and even consumer products.
https://piramidal.ai/“We’re training an AI model on brainwave data the same way ChatGPT is trained on text,” Kris Pahuja, Piramidal co-founder, told VentureBeat.
“It is the largest model ever trained on EEG data.”Today, when patients with brain-related conditions seek medical treatment, their EEG brain waves are mapped, then inspected by neurologists. But this can be highly time-consuming and error-prone, with a margin of error up to 30%, according to Pahuja.
Compounding this is the fact that there is an “extreme shortage” of neurologists — particularly those who can interpret EEGs — in the U.S. Pahuja pointed out that patients’ brain waves are recorded for several days or weeks when they are in the intensive care unit (ICU) — and no human could possibly go through all that. Instead, physicians take random samples and perform quick pattern recognition, but this can miss out on a lot of diagnosis.
EEG data is also incredibly complex, difficult to interpret and has significant signal variability. Pahuja pointed out that when someone is looking at an MRI image, for instance, they are looking at an image in one distinct period of time.
But an EEG, by contrast, is “very difficult to read, it changes thousands of times a second across 10 to 20 channels,” said Pahuja. He noted that even specialized doctors can miss many details, and some may only be trained in certain areas such as epilepsy or brain injury, so they don’t know all the markers to look for.
“We want to train our model to be at the level of an expert neurologist, but also not miss anything while an EEG is going on,” said Pahuja.
The company is first fine-tuning its model for the neuro ICU; that product will be able to ingest EEG data and interpret in near-real time, providing outputs to medical staff on occurrence and diagnosis of disorders such as seizures, traumatic brain bleeding, inflammations and other brain dysfunctions.
“It is truly an assistant to the doctor,”
By automating analysis and enhancing understanding through large models, personalized treatment can be revolutionized and diseases can be predicted earlier in their progression, he noted.
And, as wireless EEG sensors become more mainstream, models like Piramidal’s can enable the creation of personalized agents that “continuously measure and monitor brain health.”“These agents will offer real-time insights into how patients respond to new treatments and how their conditions may evolve,” said Sakellariou.
... The revolutionary model was initially inspired by Sakellariou’s experiences in various EEG studies, ranging from
psychedelics to
sleep research — both as a subject and an observer. In these studies, he explained, a technician attaches electrodes to the scalp and the system records brainwaves.
... But for Piramidal, the ICU is just the start, according to its founders:
Their model has significant potential beyond that niche area of medicine. In the near future, it’s possible that humans will have the opportunity for “quantified introspection” through everyday devices such as earphones equipped with neural sensors, Sakellariou pointed out. For example, we could measure how stress levels decrease after reducing screen time, train ourselves to enhance meditation by monitoring relaxation levels in a closed loop, or
boost memory during periods of “intense learning” through targeted auditory stimuli during specific sleep stages.
“All of this will be possible via personalized agents powered by large-scale models like ours,” said Sakellariou.
--------------------------------------------------------
--------------------------------------------------------
... boost memory during periods of “intense learning”... Hmm? --------------------------------------------------------
Non-invasive Vagus Nerve Stimulation (nVNS) Is Effective at Accelerating Foreign Language Learninghttps://markets.businessinsider.com/news/stocks/non-invasive-vagus-nerve-stimulation-nvns-is-effective-at-accelerating-foreign-language-learning-1033626175ROCKAWAY, N.J., Aug. 01, 2024 -- electroCore, Inc., a commercial-stage bioelectronic medicine and wellness company, today announced that the
Air Force Research Laboratories (AFRL) published a paper entitled
“Transcutaneous Cervical Vagus Nerve Stimulation Enhances Second-Language Vocabulary Acquisition While Simultaneously Mitigating Fatigue and Promoting Focus” in
Scientific Reports on July 26, 2024. The paper is based on a study that was conducted at the
Defense Language Institute (DLI) in Monterey, CA, the U.S. Department of Defense’s premier language school. The study was supported by Defense Advanced Research Projects Agency (DARPA)/AFRL within the
DARPA Targeted Neuroplasticity Training (TNT) program.The study recruited 36 student participants from DLI’s Arabic school house (nVNS = 18 & Sham = 18). Each subject was assessed on day 1 to establish a baseline. On days 2-4, two 2-minute nVNS stimulation treatments were self-administered by the subject, each before and after training. Assessments were taken each treatment day, and on day 5 where there was no treatment, assessments were conducted to assess possible carryover effects. The study showed a significant positive effect of nVNS over sham (p=0.025) on language recall, thereby suggesting nVNS ability to significantly improve the recall of a foreign language compared to sham. The improvement achieved through nVNS treatment on days 2-4 was maintained on day 5 demonstrating that the recall advantage that emerged during training was sustained after the completion of treatment.
All participants completed the AFRL Mood questionnaire on each day (1-5) of the study. From the
a priori-selected three scales of the AFRL Mood Questionnaire, participants receiving nVNS showed significant increases compared to participants receiving sham stimulation in energy (p=0.036) and focus (p=0.001) over the course of each training session. Their calm score also trended towards an improvement from nVNS.
Dr. Richard McKinley, of the Air Force’s 711th Human Performance Wing, Human Effectiveness Directorate and an author of the paper, commented, “We are pleased to have successfully published the first randomized, double-blind sham-controlled trial demonstrating the ability of nVNS to accelerate the learning of Arabic vocabulary in students at the Defense Language Institute. Equally impressive were the improvements in the subject’s energy and mood despite the rigors of the training program. This study is consistent with other data that suggests that nVNS may be a viable tool to enhance warfighter training and resilience in a range of areas.”
“We congratulate and thank the teams at DLI and AFRL for the dedicated work on this study as well as DARPA for their sponsoring the study” commented Dr. Peter Staats, Chief Medical Officer of electroCore. “Cognitive performance and skill acquisition are central to the mission of many institutions in a wide variety of sectors including educational, commercial, and military. This study suggests nVNS could accelerate these efforts.”
Transcutaneous cervical vagus nerve stimulation enhances second-language vocabulary acquisition while simultaneously mitigating fatigue and promoting focus,
Scientific Reports, (2024)
https://www.nature.com/articles/s41598-024-68015-4------------------------------------------------------------
Capt. Ramsey: Speaking of horses, did you ever see those Lipizzaner stallions?
...
Capt. Ramsey: Some of the things they do, uh, defy belief. Their training program is simplicity itself. You just stick a cattle prod up their ass and you can get a horse to deal cards.
Capt. Ramsey: Simple matter of voltage
- Crimson Tide - 1995---------------------------------------------------------
10 years ago ... Science Fiction or Fact: Instant, 'Matrix'-like Learninghttps://www.livescience.com/34020-matrix-learning-kung-fu.html... This sort of indirect, subliminal learning could eventually translate into teaching someone how to, say, play piano or do a judo chop.
"It's not like 'The Matrix' - yet," said Takeo Watanabe, a professor of neuroscience at Boston University and lead author of the decoded-neurofeedback study.
"But this can be developed to be a very strong tool which could realize some aspects of what was shown in the movie."------------------------------------------------------------
-----------------------------------------------------------
Will EEG Be Able to Read Your Dreams? The Future of the Brain Activity Measure as It Marks 100 Yearshttps://medicalxpress.com/news/2024-08-eeg-future-brain-years.htmlA survey, led by University of Leeds academics, saw respondents—with 6,685 years of collective experience—presented with possible future developments for EEG, ranging from those deemed "critical to progress" to the "highly improbable," and asked to estimate how long it might be before they were achieved. The results are published in the journal Nature Human Behaviour.
... Real-time, reliable diagnosis of brain abnormalities such as seizures or tumors is believed to be just 10–14 years away, while the probability of reading the content of dreams and long-term memories is judged to be more than 50 years away by some experts
It may be surprising to many that—according to the survey—within a generation we could all be carrying around our own personal, portable EEG.
One hundred years of EEG for brain and behaviour research,
Nature Human Behaviour, (2024)
https://www.nature.com/articles/s41562-024-01941-5