This may come in handy in the future ...
Clinical Trial Shows Alternate-Day Fasting a Safe Alternative to Caloric Restrictionhttps://medicalxpress.com/news/2019-08-clinical-trial-alternate-day-fasting-safe.htmlIn recent years there has been a surge in studies looking at the biologic effects of different kinds of fasting diets in both animal models and humans. These diets include continuous calorie restriction, intermittent fasting, and
alternate-day fasting (ADF). Now the largest study of its kind to look at the effects of strict ADF in healthy people has shown a number of health benefits. The participants alternated 36 hours of zero-calorie intake with 12 hours of unlimited eating. The findings are reported August 27 in the journal
Cell Metabolism.
... "We found that on average, during the 12 hours when they could eat normally, the participants in the ADF group compensated for some of the calories lost from the fasting, but not all," says Harald Sourij, a professor at the Medical University of Graz. "Overall, they reached a mean calorie restriction of about 35% and lost an average of 3.5 kg [7.7 lb] during four weeks of ADF."
The investigators found several biological effects in the ADF group:- The participants had fluctuating downregulation of amino acids, in particular the amino acid methionine. Amino acid restriction has been shown to cause lifespan extension in rodents.
- They had continuous upregulation of ketone bodies, even on nonfasting days. This has been shown to promote health in various contexts.
- They had reduced levels of sICAM-1, a marker linked to age-associated disease and inflammation.
- They had lowered levels of triiodothyronine without impaired thyroid gland function. Previously, lowered levels of this hormone have been linked to longevity in humans.
- They had lowered levels of cholesterol.
- They had a reduction of lipotoxic android trunk fat mass—commonly known as belly fat.
"The elegant thing about strict ADF is that it doesn't require participants to count their meals and calories: they just don't eat anything for one day."... "Why exactly calorie restriction and fasting induce so many beneficial effects is not fully clear yet," ... "The reason might be due to evolutionary biology," Madeo explains. "Our physiology is familiar with periods of starvation followed by food excesses. It might also be that continuous low-calorie intake hinders the induction of the age-protective autophagy program, which is switched on during fasting breaks."Open Access: Cell Metabolism, Stekovic, Hofer, and Tripolt et al.: "
Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans."