After-effects from the Pfizer/BioNTech Covid vaccine, such as chills, headache and fatigue, are more common among those who have previously had Covid itself, according to data released by the team behind “the Covid Symptom Study”.
The data was collected from those who had their first dose before 4 January 2021 and only relates to those who received the Pfizer/BioNTech Covid vaccine. In total the dataset covers 40,000 vaccine doses, with some participants having received two doses of the jab.
The results, collected by the team from users of the Zoe Covid Symptom Study app, found that
33% of people who have previously had Covid reported at least one such side effect within a week of receiving the jab (the figure covers effects that occurred at least once after the first or the second dose).
For those who had not previously had Covid the figure was 19%.
The findings chime with previous discovery that after-effects from various Covid vaccines appear to be stronger after the second dose than the first, as flagged by the US Food and Drug Administration.
The Covid Symptom Study data also suggests this, with 14% of people reporting at least one after-effect within a week of their first dose compared with 22% after their second dose. Again this is likely to be because the body’s immune system responds more forcefully when exposed to the same antigens for a second time.
https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccine--------------------------------------------
One In 20 People Likely to Suffer from ‘Long COVID’https://covid.joinzoe.com/us-post/long-covid ... The latest analysis of data from thousands of users of the COVID Symptom Study app from ZOE, published as a preprint, shows that one in 20 people are likely to suffer from COVID-19 symptoms lasting more than 8 weeks. We also found that it’s possible to predict who is likely to develop long COVID based on the very earliest signs of their illness. The more different symptoms a person experienced within the first week of illness, the more likely they were to develop long COVID. Using this together with age, gender and body mass index meant we could accurately predict who is most at risk of developing long-term symptoms.
... Overall, the team found that while most people with COVID-19 reported being back to normal in 11 days or less, around one in seven (13.3%, 558 users) had symptoms lasting for at least 4 weeks, with around one in 20 (4.5%, 189 users) staying ill for 8 weeks and one in fifty (2.3%, 95 users) suffering for longer than 12 weeks.
Extrapolating out to the general UK population, which has a different age and gender makeup compared with the COVID Symptom Study app users, the team estimated that around one in seven (14.5%) of people with symptomatic COVID-19 would be ill for at least 4 weeks, one in 20 (5.1%) for 8 weeks and one in 45 (2.2%) for 12 weeks or more.
The researchers discovered that older people are much more likely to get long COVID than younger people, although it does occur across all ages. Long COVID affects around 10% of 18-49 year olds who become unwell with COVID-19, rising to 22% of over 70s. Weight also plays a role, with people developing long COVID having a slightly higher average BMI than those with short COVID.
Although men are more likely to be admitted to hospital with COVID-19, women appear to be slightly more likely to suffer from long COVID than men (14.5% compared with 9.5%), but only in the younger age group.
The researchers also found that people with asthma were more likely to develop long COVID, although there were no clear links to any other underlying health conditions.
Importantly, the more symptoms a person had in the first week, the more likely they were to go on to develop long COVID.
The team found that long COVID symptoms fell into two broad groups. One was dominated by respiratory symptoms such as cough and shortness of breath, as well as fatigue and headaches. The second group was ‘multi-system’, affecting many parts of the body including the brain, gut and heart.
Long COVID sufferers also reported heart symptoms such as palpitations or fast heartbeat, as well as pins and needles or numbness, and problems concentrating (‘brain fog’). People who experienced a wide range of symptoms across many body systems were more likely to need a hospital assessment.
People with long COVID were also twice as likely to report that their symptoms had come back again after recovering (relapse) compared with those having short COVID (16% vs 8.4%).
Given that one in twenty people with COVID-19 are likely to be affected by long COVID, the absolute number of people affected by long COVID will only increase as the pandemic wears on, adding up to potentially hundreds of thousands in the UK and millions worldwide ... Having such large numbers of people affected means specialist services need to be set up urgently with the full financial help for hospitals and GPs.
Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the Covid Symptoms Study Apphttps://www.medrxiv.org/content/10.1101/2020.10.19.20214494v1 ----------------------------------------------
Study: International Travel Biggest Factor In Death RateEarly restrictions on international travel might have made a difference in the spread of pandemic in western Europe, including the UK, a new study has found.
Restrictions on international travel had the greatest impact on death rates, according to a study from the University of Aberdeen.
https://www.abdn.ac.uk/news/14653/They found a million international arrivals was associated with a 3.4% increase in Covid-19 deaths during the first wave of the pandemic.