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Author Topic: An Omega-3 That’s Poison for Cancer Tumors  (Read 629 times)

morganism

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An Omega-3 That’s Poison for Cancer Tumors
« on: June 14, 2021, 07:33:03 PM »
hope this holds up, is a simple function.

The poison acts on tumor cells via a phenomenon called ferroptosis, a type of cell death linked to the peroxidation of certain fatty acids. The greater the amount of unsaturated fatty acids in the cell, the greater the risk of their oxidation. Normally, in the acidic compartment within tumors, cells store these fatty acids in lipid droplets, a kind of bundle in which fatty acids are protected from oxidation. But in the presence of a large amount of DHA, the tumor cell is overwhelmed and cannot store the DHA, which oxidizes and leads to cell death. By using a lipid metabolism inhibitor that prevents the formation of lipid droplets, researchers were able to observe that this phenomenon is further amplified, which confirms the identified mechanism and opens the door to combined treatment possibilities.

For their study, UCLouvain researchers used a 3D tumor cell culture system, called spheroids. In the presence of DHA, spheroids first grow and then implode. The team also administered a DHA-enriched diet to mice with tumors. The result: tumor development was significantly slowed compared to that in mice on a conventional diet.

This UCLouvain study shows the value of DHA in fighting cancer. “For an adult,” the UCLouvain researchers stated, “it’s recommended to consume at least 250 mg of DHA per day. But studies show that our diet provides on average only 50 to 100 mg per day. This is well below the minimum recommended intake.”

https://scitechdaily.com/an-omega-3-thats-poison-for-cancer-tumors/

Reference: 11 June 2021, Cell Metabolism.
DOI: 10.1016/j.cmet.2021.05.016

Jim Hunt

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #1 on: June 14, 2021, 09:03:09 PM »
So just eat lots of fish?

Where to get at least 250 mg of DHA per day in your food if you're vegan/vegetarian?
Reality is merely an illusion, albeit a very persistent one - Albert Einstein

SteveMDFP

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #2 on: June 14, 2021, 11:01:16 PM »
So just eat lots of fish?

Where to get at least 250 mg of DHA per day in your food if you're vegan/vegetarian?

Hard to find, but algae oil.  Fish don't make their own DHA, they get it in the food chain.
If you don't mind eating tiny animals, krill oil would also do the trick.  That's more widely available.

If fish knew how healthy their flesh was for humans, I'm sure fish would volunteer to be eaten.

WildFit

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #3 on: June 15, 2021, 12:43:37 AM »
So just eat lots of fish?

Where to get at least 250 mg of DHA per day in your food if you're vegan/vegetarian?

Nuts for one, wanna know more google is your friend but there are plenty of non-cadaverous sources.  :) :) :) :) :)


Of course you mostly have to scroll down a bit because fish and such are  usually on top.

ivica

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #4 on: June 15, 2021, 12:03:13 PM »
This do not answers Jim's question, anyway - blog: Plant-Based Omega-3: What is ALA? | Fullscript

Quote
How to get omega-3 as a vegan or vegetarian
You can find omega-3 in land-based plants containing ALA or sea-based plants that contain EPA and DHA, but the latter must be consumed as extracts in supplemental format. (7) Examples of ALA-containing whole foods include flaxseeds and walnuts. (2) When ALA is consumed, it’s converted by enzymes in our bodies into eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

i have to eat so i eat what i have :), like purslane - showing up these days everywhere in garden, even in pots...


nukefix

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #5 on: June 15, 2021, 03:51:48 PM »
ALA won't cut it but as mentioned EPA&DHA are available from vegan sources.

SteveMDFP

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #6 on: June 15, 2021, 07:45:53 PM »
ALA won't cut it but as mentioned EPA&DHA are available from vegan sources.

Exactly.  Sources such as nuts, flax, and safflower oil may contain abundant ALA, but negligible EPA or DHA.  DHA was the original fatty acid under discussion.  The body can convert some ALA to DHA, but to a very limited extent.  See;

Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?
https://pubmed.ncbi.nlm.nih.gov/9637947/

"The parent fatty acid ALA (18:3n-3), found in vegetable oils such as flaxseed or rapeseed oil, is used by the human organism partly as a source of energy, partly as a precursor of the metabolites, but the degree of conversion appears to be unreliable and restricted. More specifically, most studies in humans have shown that whereas a certain, though restricted, conversion of high doses of ALA to EPA occurs, conversion to DHA is severely restricted. The use of ALA labelled with radioisotopes suggested that with a background diet high in saturated fat conversion to long-chain metabolites is approximately 6% for EPA and 3.8% for DHA. With a diet rich in n-6 PUFA, conversion is reduced by 40 to 50%."


So it really is fish oil for pescatarians, algae oil for vegans.

WildFit

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #7 on: June 15, 2021, 10:23:58 PM »


So it really is fish oil for pescatarians, algae oil for vegans.


While thanking for the detailed explanations that are one of the best ever read in a few lines, one question as to the "Oils"

Why are oils that much promoted? I usually recommend to have the original, means olives instead of olive oil if possible, fish instad of fish oil and algea instead of algae oil. The original sources of any oil IMO have huge benefits themselves and then the energy to volume relation is somehow better for people who tend to eat greater volumes of food.

What do you think?

SteveMDFP

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #8 on: June 15, 2021, 10:51:18 PM »
So it really is fish oil for pescatarians, algae oil for vegans.

While thanking for the detailed explanations that are one of the best ever read in a few lines, one question as to the "Oils"

Why are oils that much promoted? I usually recommend to have the original, means olives instead of olive oil if possible, fish instad of fish oil and algea instead of algae oil. The original sources of any oil IMO have huge benefits themselves and then the energy to volume relation is somehow better for people who tend to eat greater volumes of food.

What do you think?

Well, yes.  It's probably better to get these oils from actual food rather than supplements.  American Heart Association recommends eating fish for cardiac health, not supplements.  I believe the observational evidence is stronger for fish than for supplements.

This was more clearly seen with e.g. beta-carotene and cancer.  People with diets high in beta carotene were noted to have lower rates of cancer.  Under experimental protocols, however, beta carotene supplements did not decrease cancer rates.  See, for example:

Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial
https://academic.oup.com/jnci/article/101/1/14/914826?login=true

There are a lot more components to real food than just a supplement or two will contain.  This reminds me to put more salmon and sardines on my shopping list.  And holy mackerel !

be cause

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #9 on: June 16, 2021, 12:46:37 AM »
LOL .. just in from packing the sardines for a mini-holiday with mother (93); after enjoying salmon for lunch and kippers for tea . Holy mackerel will have to wait 'till we get to Bunagee . :)
2007 + 5 = 2012 + 4 = 2016 + 3 = 2019 + 2 = 2021 + 1 .. you gotta laugh .. :)

morganism

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #10 on: June 20, 2021, 09:54:48 PM »
good analysis folks, thanks.

Also, do not take beta carotene if you are a smoker. They had to stop a study on using for heart and cancer, and had to halt the study cause all the smokers started dieing.

Rodius

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #11 on: June 23, 2021, 04:39:44 AM »
good analysis folks, thanks.

Also, do not take beta carotene if you are a smoker. They had to stop a study on using for heart and cancer, and had to halt the study cause all the smokers started dieing.

You would think it would be better to stop the smokers from smoking than to stop a study .... :)

Human Habitat Index

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Re: An Omega-3 That’s Poison for Cancer Tumors
« Reply #12 on: July 21, 2021, 04:02:57 AM »
Prof. Thomas Seyfried - 'Cancer as a Metabolic Disease: Implications for Novel Therapies'

There is a principle which is a bar against all information, which cannot fail to keep a man in everlasting ignorance. That principle is contempt prior to investigation. - Herbert Spencer