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Sigmetnow

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Neuralink
« on: November 29, 2022, 03:23:25 PM »
—- Neuralink
Nov 30, 6 pm PT.
 
➡️ pic.twitter.com/I2J89Q7CYW 

14 seconds. Typing. Maybe someone using Neuralink???  “Please join us for show and tell”
 
11/24/22, 12:01 AM. https://twitter.com/neuralink/status/1595643786872225794

 —-
Quote
Ryan Tanaka 🤙✈️🌎.  @RyanTanaka3.
[host of @neurapod 
Neura Pod (Neuralink Updates) - YouTube
https://m.youtube.com/c/neurapod  ]
 
Neuralink is working on solving these brain/ spine problems:
 
- Memory loss
- Hearing loss
- Blindness
- Paralysis
- Depression
- Insomnia
- Extreme pain
- Seizures
- Anxiety
- Addiction
- Strokes
- Brain damage
11/24/22 https://twitter.com/ryantanaka3/status/1595667565803868160

—-
➡️ pic.twitter.com/JbZaoXBLxY
1 min. Neuralinked monkey playing pong with his mind. (While sipping on a banana smoothie.)
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Sigmetnow

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Re: Neuralink
« Reply #1 on: November 30, 2022, 03:20:36 AM »
Quote
Metro @MetroUK
The co-founder of @neuralink has revealed plans for an eye implant that could one day provide a cure for blindness 🤯
 
Here's what we know so far:
  —
Called the ‘Science Eye’, it plans to tackle to distinct types of blindess for which there is currently no cure: retinitis pigmentosa (RP) and dry age-related macular degeneration (AMD).
  —
As you’d expect from someone who worked with Elon Musk to build a brain-computer interface company, the Science Eye is suitably sci-fi...  pic.twitter.com/519gPXaoGD
  —
It will work by stimulating the optic nerve with an implanted, flexible ultradense microLED display panel inserted directly over the retina. The company will then employ gene therapy to act as a go-between and link the two.  pic.twitter.com/UT8dS2GWct
  —
Eventually, the Science Eye could work as a brain-computer interface itself and bestow cyborg-style benefits to wearers 🤯
This could include removing the need for glasses or even serving as a virtual reality device instead of a clunky headset 🤓
  —
@maxhodak_, the former Neuralink president, is behind the technology and says his startup Science Corp has already raised $160 million (£132 million) to commercialise the tech.
  —
Hodak’s company is going down a different route than Neuralink, which drills holes in a patient’s skull to insert electrodes into the brain. Instead, Science Corp wants to use photoreceptors to pass information through the optic nerve and into the brain.
  —
Would you ever consider getting a brain implant?
[poll results:  yes 54%, no 46%]
  —
And while the company says it will initially start work on animals, it hopes to get the implant into human patients in the not-too-distant future 👀

For the full story 👇
 
Cyborg eye implant could one day restore sight by linking to the brain | Metro News
https://metro.co.uk/2022/11/25/cyborg-eye-implant-could-one-day-restore-sight-by-linking-to-the-brain-17827214/
 
11/25/22 https://twitter.com/metrouk/status/1596118693351915521
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Sigmetnow

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Re: Neuralink
« Reply #2 on: November 30, 2022, 07:25:22 PM »
—- Update from @neuralink at 6pm PT
Quote
Neuralink
We’ll be doing a live Q&A during today’s event. If you have a question you’d like to ask, reply here.
11/30/22, 10:02 AM. https://twitter.com/neuralink/status/1597969445430865923
 
Neuralink Show and Tell, Fall 2022 - YouTube



Potential strong demand for Neuralink as a cure for tinnitus.
Quote
@elonmusk answered my question about Neuralink as a possible cure for tinnitus. My question is “once proven safe, will there be an age limit to receiving a Neuralink implant”?
I would be a willing recipient! 
11/30/22 https://twitter.com/jameswlaw1/status/1597982424839106561
Other replies also welcome such a cure.
⬇️ Twitpic below.

The Cost of a Neuralink Implant - YouTube
10 min. vid.   $3-5k including insurance.
 
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Sigmetnow

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Re: Neuralink
« Reply #3 on: December 01, 2022, 06:39:13 PM »
Yes, the monkeys are typing.  But it’s a game for them — they still can’t spell. 😅

Neurapod
SUPERCUT: Neuralink Show & Tell Event (23 Minutes)


Musk’s Neuralink Hopes to Implant Computer in Human Brain in Six Months
The startup awaits implant approval while already working on curing paralysis
November 30, 2022
Quote
Elon Musk’s Neuralink Corp. aims to start putting its coin-sized computing brain implant into human patients within six months, the company announced at an event at its Fremont, Calif. headquarters on Wednesday evening.

Neuralink has been refining the product, which consists of a tiny device and electrode-laced wires, along with a robot that carves out a piece of a person’s skull and implants it into the brain. Ongoing discussions with the US Food and Drug Administration have gone well enough for the company to set a target of its first human trials within the next six months, according to Musk.
https://www.bloomberg.com/news/articles/2022-12-01/musk-s-neuralink-hopes-for-human-trials-approval-within-six-months

Quote
“We are now confident that the Neuralink device is ready for humans, so timing is a function of working through the FDA approval process.”
11/30/22, 10:19 PM. https://twitter.com/elonmusk/status/1598154904635596802

Quote
"My prime motivation for Neuralink was the question: 'What do we do if there is a superintelligence that is much smarter than human beings? How do we, as a species, mitigate the risk or, in a benign scenario, go along for the ride?'"
11/30/22 https://twitter.com/elonmusk/status/1598155318319775746
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vox_mundi

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Re: Neuralink
« Reply #4 on: December 06, 2022, 08:49:32 PM »
Musk’s Neuralink Faces Federal Inquiry After Killing 1,500 Animals In Testing
https://www.theguardian.com/technology/2022/dec/05/neuralink-animal-testing-elon-musk-investigation

Elon Musk's brain-computer interface company Neuralink is under investigation by the US Department of Agriculture for possible animal welfare violations amid allegations from current and former employees that the company abused animals in slapdash research leading to "hack job" surgeries that led to needless pain and suffering of animals before they were euthanized, spurred by Musk's rushed timelines, according to documents reviewed by Reuters and sources familiar with the investigation and company operations.

The federal investigation, which has not been previously reported, was opened in recent months by the US Department of Agriculture’s inspector general at the request of a federal prosecutor, according to two sources with knowledge of the investigation. The inquiry, one of the sources said, focuses on violations of the Animal Welfare Act, which governs how researchers treat and test some animals.

The investigation has come at a time of growing employee dissent about Neuralink’s animal testing, including complaints that pressure from Musk to accelerate development has resulted in botched experiments, according to a Reuters review of dozens of Neuralink documents and interviews with more than 20 current and former employees. Such failed tests have had to be repeated, increasing the number of animals being tested and killed, the employees say. The company documents include previously unreported messages, audio recordings, emails, presentations and reports.

... In all, the company has killed about 1,500 animals, including more than 280 sheep, pigs and monkeys, following experiments since 2018, according to records reviewed by Reuters and sources with direct knowledge of the company’s animal-testing operations. The sources characterized that figure as a rough estimate because the company does not keep precise records on the number of animals tested and killed. Neuralink has also conducted research using rats and mice.

Current and former Neuralink employees say the number of animal deaths is higher than it needs to be for reasons related to Musk’s demands to speed research. Through company discussions and documents spanning several years, along with employee interviews, Reuters identified four experiments involving 86 pigs and two monkeys that were marred in recent years by human errors. The mistakes weakened the experiments’ research value and required the tests to be repeated, leading to more animals being killed, three of the current and former staffers said. The three people attributed the mistakes to a lack of preparation by a testing staff working in a "pressure-cooker environment".

Overall, employees blamed the avoidable accidents on Musk pushing researchers for faster progress with rushed timelines and deadlines.

One employee, in a message seen by Reuters, wrote an angry missive this year to colleagues about the need to overhaul how the company organizes animal surgeries to prevent “hack jobs”. The rushed schedule, the employee wrote, resulted in under-prepared and over-stressed staffers scrambling to meet deadlines and making last-minute changes before surgeries, raising risks to the animals.

This year, the chief executive sent staffers a news article about Swiss researchers who developed an electrical implant that helped a paralyzed man to walk again. “We could enable people to use their hands and walk again in daily life!” he wrote to staff at 6.37am Pacific time on 8 February. Ten minutes later, he followed up: “In general, we are simply not moving fast enough. It is driving me nuts!”

On several occasions over the years, Musk has told employees to imagine they had a bomb strapped to their heads in an effort to get them to move faster, according to three sources who repeatedly heard the comment. On one occasion a few years ago, Musk told employees he would trigger a “market failure” at Neuralink unless they made more progress, a comment perceived by some employees as a threat to shut down operations, according to a former staffer who heard his comment.

One former employee who asked management several years ago for more deliberate testing was told by a senior executive it wasn’t possible given Musk’s demands for speed, the employee said. Two people told Reuters they had left the company over concerns about animal research.

... The mistakes leading to unnecessary animal deaths included one instance in 2021 when 25 out of 60 pigs in a study had devices that were the wrong size implanted in their heads, an error that could have been avoided with more preparation, according to a person with knowledge of the situation and company documents and communications reviewed by Reuters.

The mistake raised alarm among Neuralink’s researchers. In May 2021, Viktor Kharazia, a scientist, wrote to colleagues that the mistake could be a “red flag” to FDA reviewers of the study, which the company planned to submit as part of its application to begin human trials. His colleagues agreed, and the experiment was repeated with 36 sheep, according to the person with knowledge of the situation. All the animals, both the pigs and the sheep, were killed after the procedures, the person said.

On another occasion, staff accidentally implanted Neuralink’s device on the wrong vertebra of two different pigs during two separate surgeries, according to two sources with knowledge of the matter and documents reviewed by Reuters.

The company veterinarian Sam Baker advised his colleagues to immediately kill one of the pigs to end her suffering.

“Based on low chance of full recovery … and her current poor psychological wellbeing, it was decided that euthanasia was the only appropriate course of action,”
Baker wrote colleagues about one of the pigs a day after the surgery, adding a broken heart emoji. 💔

Neuralink executives have said publicly that the company tests animals only when it has exhausted other research options, but documents and company messages suggest otherwise. During a 30 November presentation the company broadcast on YouTube, for example, Musk said surgeries were used at a later stage of the process to confirm that the device worked rather than to test early hypotheses. “We’re extremely careful,” he said, to make sure that testing is “confirmatory, not exploratory”, using animal testing as a last resort after trying other methods.

In October, a month before Musk’s comments, Autumn Sorrells, the head of animal care, ordered employees to scrub “exploration” from study titles retroactively and stop using it in the future.

Neuralink records reviewed by Reuters contained numerous references over several years to exploratory surgeries, and three people with knowledge of the company’s research strongly rejected the assertion that Neuralink avoids exploratory tests on animals. Company discussions reviewed by Reuters showed several employees expressing concerns about Sorrells’ request to change exploratory study descriptions, saying it would be inaccurate and misleading.

One noted that the request seemed designed to provide “better optics” for Neuralink.
“There are three classes of people: those who see. Those who see when they are shown. Those who do not see.” ― anonymous

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

Sigmetnow

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Re: Neuralink
« Reply #5 on: December 07, 2022, 07:40:23 PM »
How long does it take to identify which vertebra is to be operated on, or which exact unit is to be implanted?  Such mistakes sound like a too-relaxed environment, exactly the kind that needs pressure to excel.  The recent Neuralink presentation showed a myriad of ways the company is manufacturing, testing and improving the units and the surgical robot without using animals at all.

From the same article:
Quote
The total number of animal deaths does not necessarily indicate that Neuralink is violating regulations or standard research practices. Many companies routinely use animals in experiments to advance human health care, and they face financial pressure to quickly bring products to market. The animals are typically killed when experiments are completed, often so they can be examined post-mortem for research purposes.

“Reuters could not determine the full scope of the federal investigation or whether it involved the same alleged problems with animal testing identified by employees in Reuters interviews.”

“Regulatory filings show that Neuralink has passed previous USDA inspections.”
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Sigmetnow

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Re: Neuralink
« Reply #6 on: April 01, 2023, 05:24:07 PM »
Quote
Neuralink @neuralink
Bath time! 🛁 Our accelerated lifetime tester ages our implants at 4x speed. Developing new ways of expediting long-duration testing at scale allows us to iterate faster, identify low probability failures, and reduce animal use #techtuesday
3/28/23 https://twitter.com/neuralink/status/1640857347575693316
 
➡️ pic.twitter.com/n25TV32hnz. 30 sec.
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Sigmetnow

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Re: Neuralink
« Reply #7 on: May 26, 2023, 03:04:27 AM »
Elon Musk's brain implant company Neuralink announces FDA approval of in-human clinical study
Quote
Neuralink, the neurotech startup co-founded by Elon Musk, announced Thursday it has received approval from the Food and Drug Administration to conduct its first in-human clinical study.

Neuralink is building a brain implant called the Link, which aims to help patients with severe paralysis control external technologies using only neural signals. This means patients with severe degenerative diseases like ALS could eventually regain their ability to communicate with loved ones by moving cursors and typing with their minds.

"This is the result of incredible work by the Neuralink team in close collaboration with the FDA and represents an important first step that will one day allow our technology to help many people," the company wrote in a tweet.

The extent of the approved trial is not known. Neuralink said in a tweet that patient recruitment for its clinical trial is not open yet.

Neuralink is part of the emerging brain-computer interface, or BCI, industry. A BCI is a system that deciphers brain signals and translates them into commands for external technologies. …

Scientists have been studying BCI technology for decades, and several companies have developed promising systems that they hope to bring to market. But receiving FDA approval for a commercial medical device is no small task — it requires companies to successfully conduct several extremely thorough rounds of testing and data safety collection.

No BCI company has managed to clinch the FDA's final seal of approval. But by receiving the go-ahead for a study with human patients, Neuralink is one step closer to market. …
https://www.msn.com/en-us/health/other/elon-musks-brain-implant-company-neuralink-announces-fda-approval-of-in-human-clinical-study/ar-AA1bHITJ
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Bruce Steele

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Re: Neuralink
« Reply #8 on: May 26, 2023, 06:15:52 AM »
Sigmetnow, Seems like a big step. FDA approval . Not a small thing and something that when we are looking back someday , a huge step. When humans made a first direct link with AI, as an implant.
Thanks for the news, Sigmetnow , even though somehow the idea of restoring communication with the severely disabled seems reasonable lord knows where DARPA will take this. Too much SCI - FI in my youth maybe.

Sigmetnow

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Re: Neuralink
« Reply #9 on: May 26, 2023, 07:44:55 PM »
Bruce, thanks for the encouraging words.  Many attack what they do not understand, but there are people with neurological disorders including chronic pain, emotional disorders and paralysis that can find no relief with today’s medical science and desperately await new solutions this may bring.

Quote
Brian Krassenstein @krassenstein

Yesterday it was announced that the Elon Musk-founded, brain-computer-interface company Neuralink got the FDA’s approval to launch their first clinical study.

I see a lot of people attacking this news for some reason.

4 Reasons Why I'm Excited:

1) Neuralink holds the potential to revolutionize the field of medicine by providing new treatments for neurological disorders.

2) Neuralink has the potential to restore lost functionality to the human body. For instance, it could enable direct communication between the brain and prosthetic limbs, allowing amputees to control artificial limbs with greater precision and dexterity. That's just one example.

3) Neural interfaces have the potential to enhance human cognitive abilities. The best solution to the fear of AI could be the enhancement of the Human brain with AI. 

4) Neuralink's development could significantly contribute to our understanding of the human brain. By studying the brain's neural activity through implanted devices, researchers can gain information into how the brain works, potentially leading to breakthroughs in neuroscience and mental health treatment.

Please stop attacking positive things just because they are connected with someone you may not like.

The world needs progress, and this is progress!
5/26/23 https://twitter.com/krassenstein/status/1662039920054087681
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nadir

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Re: Neuralink
« Reply #10 on: May 26, 2023, 11:16:38 PM »
Ignore these rascals (Krassenstein). They are benefited by Musk, clearly. From shills of the Dem Party to cheer leaders of Musk? Something smells rotten.

Others are noting that there’s no official FDA communication (yet)
https://twitter.com/panz2021/status/1662163113519751168?s=46&t=fgkWfKCeMHNTP58vSU0TeA

Sigmetnow

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Re: Neuralink
« Reply #11 on: May 27, 2023, 01:05:05 PM »
Quote
The FDA doesn’t typically confirm approvals for human clinical trials but offered a statement Friday. “The FDA acknowledges and understands that Neuralink has announced that its investigational device exemption … for its implant/R1 robot was approved by the FDA and that it may now begin conducting human clinical trials for its device,” an agency spokesperson said in a statement Friday.

Founded in 2016, Neuralink is a privately held firm with operations in Fremont, Calif., and a sprawling campus under construction outside of Austin. The company has more than 400 employees and has raised at least $363 million, according to data-provider PitchBook.

Neuralink has brought extraordinary resources — and investor attention — to a field known as brain-computer interface, where scientists and engineers are developing electronic implants that would decode brain activity and communicate it to computers. Such technology, which has been in the works for decades, has the potential to restore function to people with paralysis and debilitating conditions like amyotrophic lateral sclerosis.

Already, companies like Blackrock Neurotech and Synchron have implanted devices in people for clinical trials, and at least 42 people globally have had brain-computer implants. Such devices have enabled feats that once belonged to the realm of science fiction: a paralyzed man fist-bumping President Barack Obama with a robotic hand; a patient with ALS typing by thinking about keystrokes; a tetraplegic patient managing to walk with a slow but natural stride.

What is Neuralink’s brain chip technology?
The company has designed an electrode-laden computer chip to be sewn into the surface of the brain, and a robotic device to perform the surgery. Neuralink is pursuing a more invasive, high-bandwidth approach than some of its rivals, betting that its configuration will transfer data from brain to computer more rapidly than devices with fewer electrodes or that sit outside the brain’s surface.

[T]he company has also given lengthy, highly technical presentations on its technology, discussing such topics as how it will mitigate the risk of brain tissue scarring and a diminishing electronic signal from the implant.

It is unclear when clinical trials might begin. A patient registry on Neuralink’s website indicates that only patients with certain conditions — including paralysis, blindness, deafness or the inability to speak — are eligible to participate.
https://www.washingtonpost.com/business/2023/05/25/elon-musk-neuralink-fda-approval/
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vox_mundi

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Re: Neuralink
« Reply #12 on: May 30, 2023, 04:15:12 PM »
“There are three classes of people: those who see. Those who see when they are shown. Those who do not see.” ― anonymous

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

Sigmetnow

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Re: Neuralink
« Reply #13 on: May 31, 2023, 12:02:58 AM »
Elon Musk:
“the Neuralink team”
“the Tesla team”
“The SpaceX team”

Media:
“Elon Musk’s Neuralink”
“Elon Musk’s Tesla”
“Elon Musk’s SpaceX”
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nadir

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Re: Neuralink
« Reply #14 on: June 04, 2023, 01:14:12 AM »
Hard agree:

https://twitter.com/drskyskull/status/1664486167553753088?s=61&t=9MiRvKAgDGxPZaLuewOvGQ

Plus: there is no confirmation from the FDA of this yet.

nadir

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Re: Neuralink
« Reply #15 on: June 06, 2023, 01:15:24 AM »
This is relevant AF


morganism

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Re: Neuralink
« Reply #16 on: August 28, 2023, 09:24:06 PM »
(caught my eye on the discussion of the new stem cell reset talk...)

(...)
Dr Daniel Poppe, a cell biologist from UWA, the Harry Perkins Institute and co-first author, said the iPS cells generated using the TNT method differentiated into many other cells, such as neuron progenitors, better than the iPS cells generated with the standard method.

https://www.uwa.edu.au/news/Article/2023/August/Scientists-find-way-to-wipe-a-cells-memory-to-reprogram-it-as-a-stem-cell

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

https://www.nature.com/articles/s41586-023-06424-7

Sigmetnow

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Re: Neuralink
« Reply #17 on: August 29, 2023, 04:18:58 AM »
Brain chip helps voiceless patient communicate at 62 words per minute
Quote
A neurological disease had robbed Pat Bennett of her ability to speak, but her brain was still sending signals of her intent to talk — and scientists were reading them.

Researchers monitored her neural activity with tiny electrode-laden devices implanted in her brain. They trained an algorithm to recognize her attempts to speak. Eventually, a team decoded her guttural utterances into text at the rate of 62 words per minute with better than 75 percent accuracy, according to a study published Wednesday in Nature.

The result is a milestone in restoring the ability to communicate to people who have lost it, more than three times as fast as the previous record, according to the study, and beginning to approach the speed of natural conversation of about 160 words per minute. The study also relied on technology that is rapidly being improved, as companies race to develop next-generation brain implants and generative artificial intelligence, fueling optimism among the authors that even better outcomes are within reach.


To translate Bennett’s attempts to speak into text, the research team relied on two tiny implants with about 120 electrodes that penetrate the brain and monitor her neural activity. They trained an algorithm to recognize her intended words by having her attempt to speak sentences on a computer screen over four months, and then combined that with a language model that predicts words based on the context.

Using a vocabulary of 125,000 words, the team’s system decoded Bennett’s attempted speech at the rate of 62 words per minute, with a 24 percent word-error rate. That is accurate enough to generally get the gist of a sentence, Henderson said, but the authors concluded that the error rate is too high for everyday use and that the system as a whole isn’t yet viable for patients.

The authors found that the error rate decreased as more channels — or electrodes reading the brain’s signals — were added. Companies including Neuralink, Paradromics, Precision Neuroscience and Blackrock Neurotech are all working on devices with more channels to get a higher resolution picture of the brain’s signals.

With those kinds of higher-bandwidth devices, the study concluded, implants in a small area of the brain could feasibly restore communication to people with paralysis at conversational speed.
https://www.washingtonpost.com/science/2023/08/23/brain-implants-convert-speech-text/
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Sigmetnow

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Re: Neuralink
« Reply #18 on: September 19, 2023, 11:44:12 PM »
BREAKING: Neuralink has announced that their first-in-Human clinical trial is now open for recruitment!
This is a medical device trial for their fully-implantable, wireless brain-computer interface.

Neuralink’s First-in-Human Clinical Trial is Open for Recruitment
Quote
We are happy to announce that we’ve received approval from the reviewing independent institutional review board and our first hospital site to begin recruitment for our first-in-human clinical trial. The PRIME Study (short for Precise Robotically Implanted Brain-Computer Interface) – a groundbreaking investigational medical device trial for our fully-implantable, wireless brain-computer interface (BCI) – aims to evaluate the safety of our implant (N1) and surgical robot (R1) and assess the initial functionality of our BCI for enabling people with paralysis to control external devices with their thoughts. 

During the study, the R1 Robot will be used to surgically place the N1 Implant’s ultra-fine and flexible threads in a region of the brain that controls movement intention. Once in place, the N1 Implant is cosmetically invisible and is intended to record and transmit brain signals wirelessly to an app that decodes movement intention. The initial goal of our BCI is to grant people the ability to control a computer cursor or keyboard using their thoughts alone. 

The PRIME Study is being conducted under the investigational device exemption (IDE) awarded by the FDA in May 2023 and represents an important step in our mission to create a generalized brain interface to restore autonomy to those with unmet medical needs. 

Those who have quadriplegia due to cervical spinal cord injury or amyotrophic lateral sclerosis (ALS) may qualify. 

If you’re interested in learning whether you may qualify for current and future Neuralink clinical trials, consider joining our Patient Registry.

To learn more:  download the study brochure here: https://neuralink.com/pdfs/PRIME-Study-Brochure.pdf
https://neuralink.com/blog/first-clinical-trial-open-for-recruitment/

⬇️ Image below from: pic.twitter.com/HMz39RWrSL 
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Sigmetnow

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Re: Neuralink
« Reply #19 on: November 11, 2023, 04:51:39 PM »
Neuralink Vision Chip
 
   ——
 
[Parent seeks help for son who has a rare eye condition and is going bind….]
 
Quote
Elon Musk
@MarcusHouse This is not much consolation, but Neuralink is working on a vision chip, which will be ready in a few years.
 
That is the next area after enabling phone/computer telepathy for those who have lost their mind-body connection. We waiting for regulatory approval for our first human.
11/7/23, https://x.com/elonmusk/status/1721908936863871243
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vox_mundi

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Re: Neuralink
« Reply #20 on: November 11, 2023, 06:09:08 PM »
Always stick with OEM ...

Will Their Bionic Eyes Be Obsolete and Unsupported Too?
https://spectrum.ieee.org/retina-implant-pixium-sa-receivership

As another retinal implant company goes broke, the tech’s future dims

Pixium Vision SA, a Paris-based company that was developing high-tech retinal implants to treat certain visual conditions, is headed into receivership while it hunts for a buyer.

Pixium’s PRIMA system, currently implanted in 47 users in Europe and the United States, comprises a tiny implant in the retina, connected to a pair of video glasses and an external computing unit. The system is currently undergoing human clinical trials for the treatment of dry age-related macular degeneration (dry AMD).

If that sounds familiar, it’s a similar set-up to the one offered by Second Sight, a U.S. retinal implant company that, in facing looming bankruptcy proceedings, suddenly left its community of users in the lurch in 2020. The fallout from the company’s abandonment of its implantees was detailed in an award-winning investigation by IEEE Spectrum last year.

https://spectrum.ieee.org/bionic-eye-obsolete

The company is currently in a legal state similar to U.S. Chapter 11 bankruptcy, heading toward a state similar to U.S. Chapter 7. That would begin a liquidation process, leaving Pixium to settle its debts as best it could, while its main assets—its staff, intellectual property, and the clinical trials—would hopefully be acquired by a buyer.

“All patients have been implanted and the postsurgical period is over. There’s always a potential that there’s a latent problem later on. But these patients will continue to be followed, and they will be taken care of by the public health systems in the countries in which they reside.”

However, he says that if Pixium cannot find a buyer in the coming weeks, their long-term prospects would be uncertain. “That’s where it becomes tricky,” says Diamond. “If there’s a problem with the device, there of course wouldn’t be individuals that could service it.”

That worries Michele Friedner, a medical anthropologist at the University of Chicago.

Quote
... “There’s all this focus on innovation and not on maintenance, the afterlife of that innovation,” .... “You want to encourage innovation, but you also want to think critically about what good innovation is if people can only use it for a small period of time. When somebody uses it and then has to stop, it can be devastating on so many levels.”

This was the experience for many Second Sight patients, as Spectrum reported in 2022, some of whom resorted to home repairs or sourcing Argus II components from other users.

would Elon 'turn off' your eyes if you miss a monthly payment? Or have your Tesla drive to the RepoMen?

------------------------------------------------------------




« Last Edit: November 11, 2023, 06:23:27 PM by vox_mundi »
“There are three classes of people: those who see. Those who see when they are shown. Those who do not see.” ― anonymous

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

Sigmetnow

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Re: Neuralink
« Reply #21 on: November 11, 2023, 10:21:54 PM »
would Elon 'turn off' your eyes if you miss a monthly payment? Or have your Tesla drive to the RepoMen?

The lack of empathy shown here is disturbing.
« Last Edit: November 11, 2023, 10:41:04 PM by Sigmetnow »
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nadir

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Re: Neuralink
« Reply #22 on: November 12, 2023, 03:43:16 PM »
would Elon 'turn off' your eyes if you miss a monthly payment? Or have your Tesla drive to the RepoMen?

The lack of empathy shown here is disturbing.

- If Neuralink was Jeff Bezos’ initiative, what would your opinion be about these inhumane experiments?
- A brain-chip interface is sought to be created; which I/O brain signals will be part of this interface exactly? Notice that the brain contains trillions of internal signals.
- Will rapid iteration process be used as in SpaceX? Let it blow until it works?


Sigmetnow

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Re: Neuralink
« Reply #23 on: November 12, 2023, 05:17:43 PM »
would Elon 'turn off' your eyes if you miss a monthly payment? Or have your Tesla drive to the RepoMen?

The lack of empathy shown here is disturbing.

- If Neuralink was Jeff Bezos’ initiative, what would your opinion be about these inhumane experiments?
- A brain-chip interface is sought to be created; which I/O brain signals will be part of this interface exactly? Notice that the brain contains trillions of internal signals.
- Will rapid iteration process be used as in SpaceX? Let it blow until it works?

If your child was going blind, or you were completely paralyzed, what your opinion be?
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nadir

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Re: Neuralink
« Reply #24 on: November 12, 2023, 07:26:35 PM »
- A brain-chip interface is sought to be created; which I/O brain signals will be part of this interface exactly? Notice that the brain contains trillions of internal signals.

I read that the Link will be able to capture ~1000 to 10000 brain signals. It is not clear to what these signals respond to, but AI will learn from the signals to eventually understand when the patient wants to move the legs etc.

So there is a bit of XXI century alchemy here: we use machine learning (which even experts are not sure how it works) to infer a complex wish from the patient (move a leg) from a handful of brain signals.

The rest is easy:
 - Create a Link that doesn’t degrade in decades and doesn’t hurt the brain
 - Avoid infections or worse
 - build an AI-managed exoskeleton that will respond to the patient brain signals flawlessly and will move their body.

- Will rapid iteration process be used as in SpaceX? Let it blow until it works?

So far, Neuralink has killed 1500 animals.
« Last Edit: November 12, 2023, 07:33:15 PM by nadir »

nadir

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Re: Neuralink
« Reply #25 on: November 22, 2023, 06:58:34 PM »

Sigmetnow

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Re: Neuralink
« Reply #26 on: November 22, 2023, 07:41:11 PM »
Neuralink @neuralink
Check out our latest video to learn more about our PRIME Study! 🧠📱
11/21/23, 8:21 PM. https://x.com/neuralink/status/1727135227565547810
 
➡️ pic.twitter.com/7zTMFzdZsF  90 sec
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vox_mundi

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Re: Neuralink
« Reply #27 on: December 06, 2023, 07:10:58 PM »
Neuralink Barrels Into Human Tests Despite Fraud Claims
https://spectrum.ieee.org/neuralink-human-trials

Elon Musk misled investors about brain chip testing, lawmakers allege

US lawmakers have urged the U.S. Securities and Exchange Commission (SEC) to investigate Elon Musk for making allegedly false statements about animal testing of a surgically implanted brain chip developed by Musk’s neurotechnology startup Neuralink.

In a letter to the SEC on 21 November, four members of the U.S. House of Representatives pushed the regulators to investigate whether Musk committed securities fraud by misleading investors about the safety of the brain implant and its role in the deaths of at least 12 monkeys, according to separate reports by Reuters and WIRED.

https://www.reuters.com/technology/us-lawmakers-ask-sec-scrutinize-musk-comments-neuralink-2023-11-22/

https://www.wired.com/story/elon-musk-nerualink-congress-sec-letter/

The allegations come as Neuralink prepares to test the brain implant in humans for the first time. The U.S. Food and Drug Administration (FDA) in May 2023 granted Neuralink approval to conduct human testing, according to Neuralink. The green light came after the agency initially rejected Neuralink’s request in early 2022, according to an investigation by Reuters.

Neuralink’s experimental device aims to give users a way to communicate directly with a computer using only their thoughts—a technology known as brain-computer interface, or BCI. The chip can record brain signals and transmit them to an external app that decodes them into computer commands such as controlling a computer cursor or keyboard. The implant is smaller than a quarter, contains over 1000 electrode channels, and is placed in the brain by a surgical robot.

In preparing for human trials, Neuralink demonstrated its device, to much fanfare, in monkeys, pigs, and sheep. But a wide range of people have sounded alarms about the company’s approach to testing animals and the safety of the device.

More than a dozen Neuralink employees told Reuters that Neuralink was rushing and botching surgeries on animals in an effort to progress more quickly to human testing. Members of the U.S. Congress have urged federal agencies to scrutinize the company over its animal studies. And the animal welfare advocacy group Physicians Committee for Responsible Medicine says it has been writing to lawmakers and federal agencies about Neuralink for nearly two years.

BCI researchers outside of Neuralink also express concerns, telling IEEE Spectrum that Neuralink seems to be moving too secretly and too fast. “I think what concerns people is that Neuralink could be cutting corners, and so far nobody has stopped them,” says Nick Ramsey, a clinical neuroscientist at University Medical Center Utrecht in the Netherlands. “There’s an incredible push by Neuralink to bypass the conventional research world, and there’s little interaction with academics, as if they think that we’re on the wrong track—that we’re inching forward while they want to leap years forward.”

The U.S. Department of Agriculture’s Inspector General in 2022 opened an investigation into Neuralink’s alleged animal abuse, according to a report from Reuters. The U.S. Department of Transportation in early 2023 also opened an investigation into the company over the potentially illegal movement of biohazardous material, according to the news agency.

In a response to animal welfare concerns, Musk on 10 September 2023 posted on X, formerly Twitter, that “no monkey has died as a result of a Neuralink implant.” Musk said the company had chosen for its studies terminal monkeys that were “close to death already. (... maybe the human volunteers will be “close to death already” too.)

Ten days later, the Physicians Committee for Responsible Medicine wrote to the SEC, claiming Musk’s comments were false. The group said it had obtained veterinary records from Neuralink’s experiments showing that at least 12 young, healthy monkeys were euthanized as a result of problems with Neuralink’s implant. The group alleged that Musk’s comments are misleading investors, and urged SEC regulators to investigate Musk and Neuralink for securities fraud.

In November, lawmakers echoed the advocacy group’s complaint in a letter to the SEC that requested an investigation. Their letter indicated that the animals suffered “debilitating health effects” from the implants, including paralysis, seizures, and brain swelling, and that at least 12 monkeys were euthanized “as a direct result of problems with the company’s implant,” according to a review of the letter by Reuters. The request came from Democratic House Representatives Earl Blumenauer of Oregon, Jim McGovern of Massachusetts, and Barbara Lee and Tony Cardenas of California, according to Reuters.
“There are three classes of people: those who see. Those who see when they are shown. Those who do not see.” ― anonymous

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

morganism

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Re: Neuralink
« Reply #28 on: December 13, 2023, 01:35:42 AM »
 Nanomaterial stimulates and regrows severed nerves like sci-fi tech


By stimulating damaged nerves, or helping restore connections between them, scientists are trying to combat movement loss caused by disease and injury


In a move that echoes a sci-fi series, researchers have developed a super-small material that was able to not only stimulate nerves in rodents, but reconnect them as well. The finding could lead to injectable particles that take the place of larger implants.

In creating the particles, researchers at Rice University started with two layers of a metallic glass alloy called Metglas and wedged a piezoelectric layer of lead zirconium titanate in between them. Piezoelectric materials generate electricity when they have mechanical forces applied to them. Metglas is a magnetostrictive material, which means it changes its shape when it has a magnetic field applied to it. In this case, the change in shape of the Metglas in the presence of magnetic pulses caused the piezoelectric material inside to generate an electrical signal. Materials that do this are known as magnetoelectric.

“We asked, ‘Can we create a material that can be like dust or is so small that by placing just a sprinkle of it inside the body you’d be able to stimulate the brain or nervous system?’” said lead author Joshua Chen, a Rice doctoral alumnus. “With that question in mind, we thought that magnetoelectric materials were ideal candidates for use in neurostimulation. They respond to magnetic fields, which easily penetrate into the body, and convert them into electric fields – a language our nervous system already uses to relay information.”

Magnetoelectrics have been investigated for use with nerves before. For example, one study in 2021 showed how magnetoelectric devices could relay signals from one to the other wirelessly, which could potentially replace the signaling ability of damaged neurons. However, a known issue with the neurological application of magnetoelectrics is that the signals the materials produce tend to be too fast for other human nerves to pick up.

To solve that, the Rice researchers built up the magnetoelectric film even more, adding platinum hafnium oxide, and zinc oxide to it. Despite this layered materials approach, the final film still only measured about 200 nanometers thick. (For comparison, a human hair measures about 90,000 nanometers wide.)

Next they tested the material in rats and found that it could not only stimulate peripheral nerves in the rodents when they were under anesthesia, but that it could also restore function in a severed sciatic nerve. It also proved to operate about 120 times faster than similar materials that have been previously developed.

Not only do the researchers believe this holds promise for super-small, potentially injectable neuroprosthetics, but they feel it could have applications in other fields as well.

“We can use this metamaterial to bridge the gap in a broken nerve and restore fast electric signal speeds,” Chen said. “Overall, we were able to rationally design a new metamaterial that overcomes many challenges in neurotechnology. And more importantly, this framework for advanced material design can be applied toward other applications like sensing and memory in electronics.”

https://newatlas.com/medical/nanomaterial-stimulates-regrows-severed-nerves/


Self-rectifying magnetoelectric metamaterials for remote neural stimulation and motor function restoration

https://www.nature.com/articles/s41563-023-01680-4

Sigmetnow

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Re: Neuralink
« Reply #29 on: January 30, 2024, 12:15:08 AM »
The first human received an implant from @neuralink yesterday and is recovering well.
 
Initial results show promising neuron spike detection.
 
1/29/24, 5:37 PM  https://x.com/elonmusk/status/1752098683024220632
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nadir

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Re: Neuralink
« Reply #30 on: January 30, 2024, 02:12:25 AM »
The first human received an implant from @neuralink yesterday and is recovering well.
 
Initial results show promising neuron spike detection.
 
1/29/24, 5:37 PM  https://x.com/elonmusk/status/1752098683024220632

Thoughts and prayers

Sigmetnow

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Re: Neuralink
« Reply #31 on: January 30, 2024, 04:45:09 AM »
The first @neuralink product is called Telepathy
   —-
Enables control of your phone or computer, and through them almost any device, just by thinking.

Initial users will be those who have lost the use of their limbs.

Imagine if Stephen Hawking could communicate faster than a speed typist or auctioneer. That is the goal.
 
1/29/24, 7:00 PM https://x.com/elonmusk/status/1752119586470949056
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Sigmetnow

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Re: Neuralink
« Reply #32 on: March 20, 2024, 11:40:29 PM »
Neuralink has posted a 9-minute video with their first implant patient, who is quadriplegic after a diving accident.
 
The patient is doing OK; he went home the day after the surgery.  The tech works.  It has improved his life.  He can now operate a laptop using just his thoughts, including chess, and language studies, and can do it lying down, which is a health bonus.  Now that he does not need a family member to be there to assist, the first night he could, he enjoyed staying up all night playing a video game.

https://twitter.com/i/broadcasts/1ypJdkXjaLNGW

3/20/24, 5:31 PM  https://x.com/neuralink/status/1770563939413496146
« Last Edit: March 20, 2024, 11:59:56 PM by Sigmetnow »
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Sigmetnow

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Re: Neuralink
« Reply #33 on: March 21, 2024, 12:22:41 AM »
BREAKING: Elon Musk just announced that Blindsight is the next Neuralink product after Telepathy.
Its aim will be to work on restoring the vision of someone who was born blind.
3/20/24, 6:39 PM   https://x.com/cb_doge/status/1770581009576165720

"Even if someone has never had vision ever, like they were born blind, we believe that we can still restore vision using Neuralink"
➡️ pic.twitter.com/NYZPaIX2qn  23 sec

Quote
Elon Musk
 
Blindsight is the next @neuralink product after Telepathy
3/20/24, 6:34 PM  https://x.com/elonmusk/status/1770579793882517633
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Sigmetnow

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Re: Neuralink
« Reply #34 on: March 22, 2024, 12:40:23 AM »
Elon Musk
Long-term, it is possible to shunt the signals from the brain motor cortex past the damaged part of the spine to enable people to walk again and use their arms normally
3/21/24, https://x.com/elonmusk/status/1770687287174582483
 
—-
Bliss Chapman [@ neuralink]
Participant #1 played a chess game while doing a live interview in front of like 10 million people and yes... he won.
3/21/24, https://x.com/chapman_bliss/status/1770862173457137799

Peťka
Bliss, thank you for the awesome work that you and Neuralink is doing, Elon has a great team of very intelligent and devoted experts who are - and will be changing - lives of so many people. You are literally giving them a new life. I have a 8 year old son with spina bifida and after seeing the video, he stated: "mama, I will be the second person to get the microchip because I really wanna walk." I know that it is not possible yet, but one day, when he is older, I believe we will meet and he will get it, he is also a huge fan of Elon 😊. Thank you so much for your work, greetings from Slovakia, Europe.
3/21/24, https://x.com/peka72356968/status/1770876225097027932
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SteveMDFP

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Re: Neuralink
« Reply #35 on: March 22, 2024, 12:58:13 PM »
BREAKING: Elon Musk just announced that Blindsight is the next Neuralink product after Telepathy.
Its aim will be to work on restoring the vision of someone who was born blind.
3/20/24, 6:39 PM   https://x.com/cb_doge/status/1770581009576165720

"Even if someone has never had vision ever, like they were born blind, we believe that we can still restore vision using Neuralink"
➡️ pic.twitter.com/NYZPaIX2qn  23 sec

Quote
Elon Musk
 
Blindsight is the next @neuralink product after Telepathy
3/20/24, 6:34 PM  https://x.com/elonmusk/status/1770579793882517633

The Neuralink technology does appear to show great promise for individuals with specific neurologic injuries and diseases.  This is great news for these individuals.

However, I'm not seeing a pathway for Neuralink to be used for normal people who want *enhanced* function.  Getting the FDA (or EU) to approve meddling with normal brains will be extremely difficult. 

On the specific case of trying to provide vision to those born blind congenitally, color me skeptical.  I recall reading that adults treated for congenital cataracts using lens implants fare very poorly.  When the developing brain has no use for the visual cortex from birth, the brain doesn't develop those systems.  Connect visual inputs to that undeveloped cortex, and I doubt the result will be positive.

Sigmetnow

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Re: Neuralink
« Reply #36 on: March 22, 2024, 05:29:14 PM »
On the specific case of trying to provide vision to those born blind congenitally, color me skeptical.  I recall reading that adults treated for congenital cataracts using lens implants fare very poorly.  When the developing brain has no use for the visual cortex from birth, the brain doesn't develop those systems.  Connect visual inputs to that undeveloped cortex, and I doubt the result will be positive.

That makes sense; particularly for early participants, the tech might be most useful on those who have lost their sight in adulthood, for example from macular degeneration. 

But as the tech improves, it might be applicable to more difficult cases, and (the software) be improved so that it works better to “train” the visual cortex.

Musk noted that the Blindsight implant is already working in monkeys, and said “Resolution will be low at first, like early Nintendo graphics, but ultimately may exceed normal human vision. (Also, no monkey has died or been seriously injured by a Neuralink device!)”
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morganism

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Re: Neuralink
« Reply #37 on: March 22, 2024, 06:32:36 PM »
would be interesting to see if the brain could be trained to see higher dimensions tho. Also UV and IR.

here is a waveguide array paper

Synthetic dimensions (SDs) are at the forefront of physics research, promising a new understanding and manipulating light beyond the confines of traditional three-dimensional space. Utilized in topological photonics, SDs pave the way for exploring complex phenomena such as quantum Hall physics and topological phase transitions in spaces that exceed our usual three dimensions. Researchers aim to utilize SDs for creating advanced systems with capabilities like synthetic gauge fields and discrete solitons, potentially revolutionizing fundamental physics.

https://dx.doi.org/10.1117/1.AP.6.2.026005     (PNAS)


Sigmetnow

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Re: Neuralink
« Reply #38 on: March 22, 2024, 07:47:18 PM »
would be interesting to see if the brain could be trained to see higher dimensions tho. Also UV and IR.

With the right sensors, software, and brain: sure!
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Sigmetnow

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Re: Neuralink
« Reply #39 on: March 22, 2024, 07:47:34 PM »
Neuralink’s first patient
 
Quote
Noland Arbaugh @ModdedQuad
 
Twitter banned me because they thought I was a bot,  @X and @elonmusk reinstated me because I am.
3/22/24, 1:39 PM  https://x.com/moddedquad/status/1771230292839145541
 
< Just commenting so I'm here for the history books -- the world's first tweet by a cyborg

===
Last Call @LastCallCNBC
"This is just the beginning," says Peter Diamandis on Elon Musk’s Neuralink. "The speed of acceleration means in the next 10 years we're going to see as much progress as we've seen in the last hundred years."
3/21/24, 8:09 PM  https://x.com/lastcallcnbc/status/1770966109476344263
➡️ pic.twitter.com/3NrXsiVOTu  1 min. AI & high-bandwidth connections from the cloud to the brain by 2033?
 
Elon Musk
Probably true
3/22/24, 2:11 AM https://x.com/elonmusk/status/1771057146609742328
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Sigmetnow

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Re: Neuralink
« Reply #40 on: March 24, 2024, 02:45:29 PM »
Neuralink’s first recipient.
Quote
Noland Arbaugh @ModdedQuad
Neuralink was kind enough to open their doors for me to tour their headquarters a few weeks back. It was an amazing experience and a day I'll never forget. This was at a company wide meeting at the end of the day. Thank you to everyone who made this possible. Hope y'all enjoy! I'm hoping to tell my story in full some day.
3/22/24, 6:09 PM  https://x.com/moddedquad/status/1771298116719002100
 
➡️ pic.twitter.com/YNa2Jtjhnk  1 hour.  Noland on stage.
 
➡️ pic.twitter.com/TbJHHg4OA3  3 min. clip from the above vid. From @BrianRoemmele.
 
Quote
Brian Roemmele
We live in a moment where those imprisoned in a body that has failed them can now soar.
We are capable of such great things.
This is the first NeuraLink recipient.
Thank you @elonmusk. Gratitude.
 
Elon Musk
Over time, I think almost all brain or spine injuries can be addressed
3/23/24, https://x.com/elonmusk/status/1771606744390578376
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Sigmetnow

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Re: Neuralink
« Reply #41 on: April 14, 2024, 04:20:47 AM »
Neuralink published their PRIME Study today. Noland, the first patient, is Neuralink's PRIME Study. He demonstrated the ability to use brain activity to command an external device. The successful procedure for Neuralink’s N1 Implant was performed at Barrow Neurological Institute. The Neuralink PRIME Study is the first of its kind.

PRIME Study Progress Update
Quote
Our First Human Implantation
 
Our first human implantation was conducted in a paralyzed adult as part of our PRIME Study and performed at Barrow Neurological Institute in Phoenix, Arizona. The surgery went extremely well, and the participant was able to go home the following day. The participant’s recovery since the surgery has been very smooth.
 
We chose to partner with Barrow based on their extensive expertise in caring for patients with complex neurological conditions. With more than 300 active clinical trials currently underway, Barrow is committed to advancing the field of neuroscience and ensuring patients have access to an array of innovative treatment options and the most advanced and compassionate care.
 
According to Michael T. Lawton, MD, president and CEO of Barrow Neurological Institute, “This operation is an impressive engineering feat and an important advancement in neurosurgery because it paves the way for new, non-biological treatments for patients with severe neurological impairments. The PRIME Study will likely be viewed as ushering in an era of brain-computer interface, or direct interaction between thoughts and implantable technology.” …
https://neuralink.com/blog/prime-study-progress-update/
 
Photos of the devices and more at the link.
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