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Author Topic: Human Stupidity (Human Mental Illness)  (Read 174045 times)

vox_mundi

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Re: Human Stupidity (Human Mental Illness)
« Reply #400 on: July 02, 2022, 09:46:57 PM »
more action than Pamplona, Spain

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A bull bison gored a man near Old Faithful at Yellowstone National Park, officials say

A Colorado man required medical treatment at a hospital after he was gored by a bull bison at Yellowstone National Park in Wyoming, officials said.

The 34-year-old man was walking with his family on a boardwalk near the Giant Geyser at Old Faithful on Monday when the bull bison charged at the group, according to a news release from the park.

----------------------------------------

Yellowstone Bison Gore Second Visitor in Three Days

Update, June 30: For the second time in three days, a bison has injured a visitor at Yellowstone National Park.

The incident occurred on Wednesday, near Storm Point on Yellowstone Lake. According to a press release from the National Park Service, the victim, a 71-year-old woman from West Chester, Pennsylvania, was walking back to her car with her daughter when they unwittingly approached a bull bison, which charged, inflicting non-life-threatening injuries.

The first incident of the year occurred on May 31, when a 25-year-old woman from Ohio was attacked near a boardwalk at Black Sand Basin, just north of Old Faithful; she was gored and thrown 10 feet (3 meters) into the air, according to an NPS statement

https://www.nps.gov/yell/learn/news/220531.htm

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Three people gored by bison in a month at Yellowstone National Park.
https://www.livescience.com/bison-attacks-yellowstone-2022

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800 pounds of pure muscle against 250 pounds of out of shape middle class moron... Three Two more and this bison achieves ACE status.
There are 3 classes of people: those who see. Those who see when they are shown. Those who do not see

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

Fiat iustitia, et pereat mundus

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #401 on: June 20, 2023, 12:38:02 AM »
Dunning–Kruger effect and flat-earthers: An exploratory analysis

Abstract
This article aims to analyze the factors influencing belief in a flat Earth. We focus on Spain, a country that sadly has some of the most relevant figures on this topic in the Spanish-speaking world. After a qualitative analysis of YouTube videos on the main channels on the subject, a survey was carried out on 1252 individuals. The results point to two conclusions. First is the presence of a considerable Dunning–Kruger effect among flat-earthers. There is a significant negative correlation between science literacy—overall and practically all its dimensions—and overconfidence in science in this group. The second, evaluated through a regression tree, confirms that the interaction of low scientific literacy and overconfidence is highly relevant in explaining the belief in a flat earth. Neither factor alone is determinant, but the combination of the two (low scientific literacy and high overconfidence) leads to high levels of flat earth belief."

https://journals.sagepub.com/doi/10.1177/09636625231166255

vox_mundi

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Re: Human Stupidity (Human Mental Illness)
« Reply #402 on: June 21, 2023, 05:18:20 PM »
Research Identifies Factors That Make Correcting Misinformation About Science More Successful
https://phys.org/news/2023-06-factors-misinformation-science-successful.html

In an article titled "A Meta-analysis of Correction Effects in Science-Relevant Misinformation" published in the journal Nature Human Behaviour, University of Pennsylvania social psychologists and communication scholars Man-pui Sally Chan and Dolores Albarracín explain the circumstances under which corrections of misinformation about science are most likely to work or fail, as well as the characteristics of the corrections most likely to succeed.

The authors conducted a meta-analysis, a quantitative synthesis of prior research, which involved 60,000 participants in 74 experiments. Each experiment either assessed belief in misinformation about science or introduced misinformation about science as accurate and then introduced corrections for the misinformation.

Although on average the corrections failed to accomplish their objectives, they worked better when the issue in the correction was emotionally more positive than the misinformation, the correction matched the ideology of the recipients, the issue was not politically polarized, and the correction provided abundant details as to why the earlier claims were false.

Can science-relevant misinformation be corrected, on average?

... The researchers found that "attempts to debunk science-relevant misinformation were, on average, not successful," said Chan, the lead author and a research associate at the Annenberg School for Communication at the University of Pennsylvania.

"Therefore, most of the science-relevant misinformation goes uncorrected even when a debunk is presented. People believe in the misinformation as much before as after the debunk. This is quite notable, because corrections in other domains, such as reports about an accident or political event, do reasonably well, as shown by past research. However, this does not occur in the domain of misinformation about science."



"We humans like to keep our rose-tinted glasses on, and we are resistant to debunking pseudoscience that feels good," said Albarracín, the Alexandra Heyman Nash University Professor of the University of Pennsylvania and director of the Science of Science Communication division of the Annenberg Public Policy Center. "It is far easier to correct hype about a chemical spill that didn't happen than about deforestation that is happening. The reason is that it's more pleasant to move from pessimistic to optimistic news rather than the other way around." Good news corrects negative misinformation more easily than bad news corrects positive misinformation, she said.

Chan and Albarracín also examined whether an individual's attitudes or beliefs "affect the success of corrections of science-relevant misinformation." They found that when the debunking contradicts people's ideology, recipients are more likely to reject the correction and reinforce their support for the misinformation.

So, for example, a person with a left-leaning ideology is disposed to accept a correction of claims opposing climate change. In contrast, when the debunking contradicts people's ideology, recipients are more likely to reject the correction and reinforce their support for the misinformation.

Another important factor is political polarization around the scientific issue being discussed. The study found that when a topic is polarized, as—for example—COVID-19 vaccination, the correction often fails. "It's more than twice as hard to debunk polarized misinformation than it is to correct non-polarized misinformation," Albarracín said.

Man-pui Sally Chan et al, A meta-analysis of correction effects in science-relevant misinformation, Nature Human Behaviour (2023)
https://www.nature.com/articles/s41562-023-01623-8

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There are 3 classes of people: those who see. Those who see when they are shown. Those who do not see

Insensible before the wave so soon released by callous fate. Affected most, they understand the least, and understanding, when it comes, invariably arrives too late

Fiat iustitia, et pereat mundus

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #403 on: December 24, 2023, 05:38:55 AM »
Researchers discover neuronal biomarkers of schizophrenia in the blood

Professor Cairns explains, “Understanding schizophrenia on a molecular level has been notoriously difficult because, until now, we’ve needed to extract tissue from the brain. This can only be done postmortem and over the past decade, we’ve only had limited access to this precious resource.

“The new technique we have pioneered, in partnership with the Australian Schizophrenia Research biobank, allowed us to analyse blood serum from 600 participants, including 230 people diagnosed with schizophrenia.

“We have been able to use blood from living people to understand what is different about the neurons in the brain. The blood contains small liposome-like vesicles that encapsulate molecules from the neurons in the brain where they originate.

“Because we were able to use blood from living clinical trial participants, we can compare with other data including MRI images, genome sequences, diagnostic instruments, and other cognitive parameters,” says Professor Cairns



paper at link:
https://drive.google.com/drive/folders/1Y_UJzHJrhKXk_mdDuURGZva-05HhvvJD


and related

Extracellular vesicle biomarkers for complement dysfunction in schizophrenia

Schizophrenia, a complex neuropsychiatric disorder, frequently experiences a high rate of misdiagnosis due to subjective symptom assessment. Consequently, there is an urgent need for innovative and objective diagnostic tools. In this study, we utilized cutting-edge extracellular vesicles' (EVs) proteome profiling and XGBoost-based machine learning to develop new markers and personalized discrimination scores (PDS) for schizophrenia diagnosis and prediction of treatment response. We analyzed plasma and plasma-derived EVs from 343 participants, including 100 individuals with chronic schizophrenia, 34 first-episode and drug-naïve (FEDN) patients, 35 individuals with bipolar disorder (BD), 25 individuals with major depressive disorder (MDD), and 149 age- and sex-matched healthy controls. Our innovative approach uncovered EVs-based complement changes in patients, specific to their disease-type and status. The EV-based biomarkers outperformed their plasma counterparts, accurately distinguishing schizophrenia individuals from healthy controls with an area under curve (AUC) of 0.895, 83.5% accuracy, 85.3% sensitivity, and 82.0% specificity. Moreover, they effectively differentiated schizophrenia from BD and MDD, with AUCs of 0.966 and 0.893, respectively. The PDS provided a personalized diagnostic index for schizophrenia and exhibited a significant association with patients' antipsychotic treatment response in the follow-up cohort.

https://pubmed.ncbi.nlm.nih.gov/37816260/


Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations

https://www.nature.com/articles/tp2016142

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #404 on: December 28, 2023, 08:32:25 AM »
Disarming The Narcissist

Do you know someone who is overly arrogant, shows an extreme lack of empathy and accountability, an inflated sense of entitlement? Do they exploit others, or engage in exaggerated, grandiose thinking?
Learn More about Narcissism
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Based on reader feedback, this fully revised and updated third edition features new information on narcissistic hypersexuality, shame, infidelity and betrayal trauma; divorcing a narcissist, and co-parenting with a narcissist.

With this how-to guide, you’ll learn how to embrace your rights, reclaim your voice, and effectively confront the challenging moments with the narcissist in your life.

Finally, you’ll learn how to set limits with your narcissist and when it’s time to draw the line on unacceptable behavior.

https://disarmingthenarcissist.com/

https://www.reddit.com/r/slatestarcodex/comments/18ruqw0/narcissistic_personality_disorder_and_the/

https://www.apa.org/pubs/journals/features/pap-pap0000145.pdf%E2%80%A8

borderline or covert narc



morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #405 on: December 30, 2023, 08:40:52 PM »
Serotonin booster leads to increased functional brain connectivity

(...)
Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects. Limited treatments currently exist, but studies in animals and humans have pointed to drugs that activate serotonin receptors as a potential therapeutic for the symptoms. However, it has remained unclear how the medication affects resting brain activity.

Now, a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, led by researchers in the Department of Psychiatry at the University of Oxford, examines the drug’s effects in healthy human adults.

Serotonin receptors and the 5-HT4-type receptors in particular are found in areas throughout the brain, including the frontal cortex, basal ganglia and hippocampus, that are known to mediate cognitive function and regulate mood. Serotonin receptors are the primary targets of anti-depressant medications, but resolving mood disturbances often does not resolve cognitive symptoms.

The researchers enlisted 50 healthy volunteers; half of them received a six-day course of prucalopride, a highly selective agonist of the 5-HT4 type serotonin receptor, whereas the other half of the participants received a placebo. Participants underwent scanning with functional magnetic resonance imaging (fMRI), including a “resting scan” where they could relax in the scanner.

“Our previous studies on prucalopride demonstrated that even at low clinical doses it can improve cognition and memory in healthy volunteers. This latest research provides a neurological mechanism by which this might occur.”

Participants who received the medication displayed more functional connectivity in their resting state (rsFC) between major cognitive networks. This included more rsFC between the central executive network (cEN), a brain network used for processing thoughts, and the posterior and anterior cingulate cortex (PCC/ACC), brain areas that regulate information processing and attention in the brain. There was also more rsFC between regions of the ACC and the lateral occipital cortex, a region that helps us pay attention to objects that matter. What’s more, medicated participants compared to placebo controls showed decreased rsFC within the default mode network (DMN), a brain network that is activated during mind wandering.

Appropriate connectivity between and within these brain networks is needed to think properly, and it’s known that this connectivity is abnormal in depression. As these same participants taking prucalopride had better scores on cognitive tests earlier that day compared to the placebo participants, this pattern of changes with prucalopride (i.e. increased rsFC within cognitive networks and decreased rsFC within the DMN) appears to be a “signature” of a drug that improves cognition.

“This provides further evidence that prucalopride is having an effect in areas of the brain that improve cognitive function – both by increasing and reducing connectivity between specific brain regions as required.”

Susannah Murphy, Associate Professor and joint senior author of the study, said: “Untreated cognitive problems have a significant impact on the quality of life of people with depression. This study adds to the growing evidence base that drugs affecting the 5-HT4 serotonin receptor hold promise as a novel way to treat depression and cognitive impairment.”

Catherine Harmer, Professor of Cognitive Neuroscience and joint senior author of the study, said: “This study adds to the evidence base that the common laxative treatment prucalopride can have important effects in the brain, particularly affecting circuits which are important for learning and memory. Together with previous data, this suggests that this drug might be useful as a pro-cognitive treatment in disorders such as depression.”


https://www.psych.ox.ac.uk/news/serotonin-booster-leads-to-increased-functional-brain-connectivity


5-HT4 Receptor Agonist Effects on Functional Connectivity in the Human Brain: Implications for Procognitive Action

https://www.sciencedirect.com/science/article/pii/S245190222300099X

Cognitive deficits are often comorbid with mood disorders and can cause significant functional impairment even after resolution of the primary mood symptoms. We do not currently have pharmacological treatments that adequately address these deficits. 5-HT4 receptor agonists show promise as potential procognitive agents in animal and early human translational studies. Optimal cognitive performance in humans is directly associated with appropriate functional connectivity between specific resting-state neural networks. However, so far the effect of 5-HT4 receptor agonism on resting-state functional connectivity (rsFC) in the brain in humans is unknown.


morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #406 on: January 11, 2024, 06:34:16 AM »
Reduced Brain Grey Matter Linked to Early Onset Psychosis


Summary: A groundbreaking study reveals a strong association between a reduction in grey matter and Early Onset Psychosis (EOP). This extensive brain imaging study is the largest of its kind in EOP, providing detailed insights into the condition.

People with EOP display reduced grey matter volume across various brain regions, distinct from other mental health disorders. This research could lead to improved diagnosis and treatment monitoring for EOP patients.

Key Facts:

    The study examined 482 individuals with EOP from multiple countries and compared them to 469 healthy controls.
    Grey matter reduction was observed across nearly all brain regions, with a significant impact on the left median cingulate, which is linked to emotions, learning, and memory.
    The study’s findings highlight the potential for this detailed brain mapping to serve as a diagnostic tool and to assess treatment effectiveness.

The study, published in Molecular Psychiatry, is the largest ever brain imaging study in EOP and has provided unprecedented levels of detail about the illness. It shows that, in contrast to other mental health disorders, people with EOP have a reduced volume of grey matter across nearly all regions of their brain. Researchers hope that this detailed mapping could be used to assist in future diagnosis, as well as to track the effects of treatment in patients with EOP.
Further analysis of the data revealed that those individuals who developed EOP at a later age had lower volumes of grey matter in a number of small brain regions compared to those with an earlier age of onset.

EOP occurs before the age of 18 during a critical period of development in the brain. Individuals diagnosed with the illness are likely to experience severe and long-lasting symptoms that respond less well to treatment. Despite this, research into EOP has been limited in sample size and statistical power.

The study represents an international effort, combining brain scans from Norway, Spain, Canada, Italy, Australia & UK, 482 individuals with EOP being compared to 469 healthy controls. An analysis of the data revealed that individuals with EOP had lower volumes of grey matter in almost all regions of the brain compared to the healthy controls, with a marked effect in the left median cingulate – an area of the brain associated with the formation and processing of emotions, learning and memory.

Dr Matthew Kempton, Reader in Neuroimaging Psychiatry at King’s IoPPN and the study’s senior author said, “Early Onset Psychosis can have a devastating impact on a person’s life and wellbeing, but our understanding of the illness is still sadly relatively limited.

“This study, the largest neuroimaging analysis of EOP to date, used newly developed technologies to combine scans from different sites to examine hundreds of thousands of data points measuring volume in the brain.

“We found that people with EOP experience a lower volume of grey matter in nearly all regions of their brains compared to people without the illness. This detailed map will hopefully provide the basis for future research, as it could help as a diagnostic tool, and even track the effectiveness of treatments.”

Further analysis of the data revealed that those individuals who developed EOP at a later age had lower volumes of grey matter in a number of small brain regions compared to those with an earlier age of onset.

Shuqing Si, the study’s first author from King’s IoPPN said, “Grey matter’s primary purpose is to process information in the brain and plays a significant role in day to day functions like memory, emotions and movement.

“This study used specially created software (ENIGMA-VBM) developed at King’s that can accurately map where there have been local increases and decreases in brain volume. It’s allowed our team to process significantly more data and has meant that our sample reflects brain scans from many parts of the world. The effectiveness of this software means we’re now investigating the brains of those with several other disorders.

https://neurosciencenews.com/grey-matter-psychosis-25439/

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #407 on: January 15, 2024, 11:30:37 AM »
It's all about the meta-crisis we all stuck in the middle of right now and which is about to drive us all over the cliff into catastrophic destruction and death. Enjoy!

1:04:02 - The Difference Between Wisdom and Intelligence
1:12:41 - Chesterton’s fence
1:13:03 - Progressive and Traditionalist as Dialectics
1:18:07 - Genetics and Intelligence vs Wisdom

https://youtu.be/_P8PLHvZygo?si=hQc0H01wbCXz5w8U&t=3842

Usually I would copy paste and then edit the transcript sections that were really good examples of the content. Which might take half an hour or more. Now, I think nah, f ' it. I'm over it. :)

This video is a repost.
« Last Edit: January 15, 2024, 11:49:09 AM by SeanAU »
It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #408 on: January 21, 2024, 06:38:54 PM »
Scientific Misconduct and Fraud: The Final Nail in Psychiatry’s Antidepressant Coffin  (site warning)
(...)
Psychiatry and Big Pharma have never disputed the adverse effects of its antidepressants, but have claimed that the great benefits of these drugs outweigh their adverse effects. Is this claim valid?

Receiving little attention by the mainstream media in 2002, the Journal of the American Medical Association (JAMA) published a study aimed at discrediting the herb St. John’s wort as an antidepressant. However, in this randomized controlled trial (RCT), in addition to one group receiving a placebo and a second group receiving St. John’s wort, there was a third group that received the standard dose of the SSRI Zoloft. The results? The placebo worked better than both St. John’s wort and Zoloft. Specifically, a positive “full response” occurred in 32 percent of the placebo-treated patients, 25 percent of the Zoloft-treated patients, and 24 percent of the St. John’s wort-treated patients.

A major reason why most of the general public never heard about this study was that it was published with the title, “Effect of Hypericum Perforatum (St John’s wort) in Major Depressive Disorder: A Randomized Controlled Trial.” Why was there no mention of Zoloft in the study title? Zoloft is manufactured by Pfizer, and the financial disclosure of this study’s lead author, psychiatrist Jonathan R. T. Davidson, states: “Dr. Davidson holds stock in Pfizer [manufacturer of Zoloft] . . . and has received speaker fees from Pfizer.”

While this 2002 study showing that the placebo worked better than both Zoloft and St John’s wort was buried, later in 2002, a large study did receive significant attention. A leading researcher of the placebo effect, Irving Kirsch, examined forty-seven drug company studies on various antidepressants. These studies included published and unpublished trials, but all had been submitted to the Food and Drug Administration (FDA), so Kirsch used the Freedom of Information Act to gain access to all data. He reported that “all antidepressants, including the well-known SSRIs . . . had no clinically significant benefit over a placebo.”
(more)
https://www.counterpunch.org/2024/01/17/scientific-misconduct-and-fraud-the-final-nail-in-psychiatrys-antidepressant-coffin/

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #409 on: January 21, 2024, 08:32:47 PM »
Quote
. . . had no clinically significant benefit over a placebo

And yet, nevertheless, in a cohort of people monitored St John's Wort and SSRI anti-depressants did in fact have a positive therapeutic effect. (according to the studies/controls)

So why is that?

Is every person built the same way? No. In the same state of "health"? No. Does aspirin work the same in all people for headaches in all occasions? Is aspirin no better than a placebo? Good question. Are X-Rays safe? Does a Bowell resection save lives?

And if a Placebo works better than a drug, then why not also dispense Placebo Tabs, just in case they work on a patient first?

This can be extended to why do cancer treatments work absolutely great on some people with X cancer but not on others?

In major depressive illnesses CBT has worked well in a % of patients as shown in studies.

Is it the therapist or is it the patient that "causes" some patients to get zero benefits?

There is much about the human body and mind we do not know how or why it works.

There is also much about the medical system that is absolutely shiot that we already know about, and much we do not because they cover it up.

Lastly, RCTs are not the last word on everything - and do not rise to the level of real evidence or hard FACTS let alone truth. It is a very good thing and wise to doubt them.

The same goes for ALL PEER -REVIEWED SCIENTIFIC RESEARCH AND STUDIES AND META STUDIES.

Including that produced by Climate Scientists -- they DO NOT KNOW EVERYTHING, even about what they claim to already Know!

iow Climate Science is less reliable than Medical Science. AT least in medical science you can see and touch things and measure things fairly accurately and reliably.

Such as you ascertain with real verifiable evidence if someone is dead or not.

If you are depressed and you take an SSRI anti-depressant and 6 months later you feel better, who has the right to tell you that Tab doesn't work any better than a Placebo?

Where is THEIR evidence the SSRI has not had a positive effect on your mental state? They did not do any research or tests to establish that - now did they? They simply ASSUMED - aka Believe - it doesn't work. 

Therefore, at the end of the day, it always comes back to who and what do you choose to believe when you yourself are not in possession of the hard evidence or the verifiable facts?

WHO DECIDES WHO IS STUPID?  ;D
It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #410 on: January 21, 2024, 08:40:45 PM »
Q: Is Brain Surgery results no better than a Placebo?
It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

Neven

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Re: Human Stupidity (Human Mental Illness)
« Reply #411 on: January 21, 2024, 10:04:26 PM »
Isn't one automatically an anti-vaxxer when criticising Big Pharma?
The enemy is within
Don't confuse me with him

E. Smith

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Re: Human Stupidity (Human Mental Illness)
« Reply #412 on: January 22, 2024, 01:26:01 AM »
Depression probably not caused by chemical imbalance: Study

For three decades, people have been deluged with information suggesting that depression is caused by a ‘chemical imbalance’ in the brain – namely an imbalance of a brain chemical called serotonin.
 
However, our latest research review shows that the evidence does not support it.
 
Although first proposed in the 1960s, the serotonin theory of depression started to be widely promoted by the pharmaceutical industry in the 1990s in association with its efforts to market a new range of antidepressants, known as selective serotonin-reuptake inhibitors or SSRIs.
 
The idea was also endorsed by official institutions such as the American Psychiatric Association, which still tells the public that ‘differences in certain chemicals in the brain may contribute to symptoms of depression’.
 
Countless doctors have repeated the message all over the world, in their private surgeries and in the media. People accepted what they were told. And many started taking antidepressants because they believed they had something wrong with their brain that required an antidepressant to put right.
 
In the period of this marketing push, antidepressant use climbed dramatically, and they are now prescribed to one in six of the adult population in England, for example.
 
For a long time, certain academics, including some leading psychiatrists, have suggested that there is no satisfactory evidence to support the idea that depression is a result of abnormally low or inactive serotonin. Others continue to endorse the theory.
 
Until now, however, there has been no comprehensive review of the research on serotonin and depression that could enable firm conclusions either way.
 
At first sight, the fact that SSRI-type antidepressants act on the serotonin system appears to support the serotonin theory of depression. SSRIs temporarily increase the availability of serotonin in the brain, but this does not necessarily imply that depression is caused by the opposite of this effect.
 
There are other explanations for antidepressants’ effects. In fact, drug trials show that antidepressants are barely distinguishable from a placebo (dummy pill) when it comes to treating depression. Also, antidepressants appear to have a generalised emotion-numbing effect which may influence people’s moods, although we do not know how this effect is produced or much about it.

https://www1.racgp.org.au/newsgp/clinical/depression-probably-not-caused-by-chemical-imbalan

"The causes of depression have been long debated, yet a common explanation holds that the culprit is “chemical imbalance” in the brain. This notion emerged, not coincidentally, in the late '80s with the introduction of Prozac—a drug that appeared to be helpful in treating depression by increasing levels of the brain neurotransmitter serotonin.

Pushed heavily by the pharmaceutical industry, as well as reputable professional organizations such as the American Psychiatric Association, this storyline has since become the dominant narrative with regard to depression, accepted by the majority of people in the U.S., and leading more and more people to think of their psychological difficulties in terms of chemical brain processes. Depression treatment, in turn, has leaned ever more heavily on antidepressant medications, widely touted as the first, and best, intervention approach."

https://www.psychologytoday.com/us/blog/insight-therapy/202207/depression-is-not-caused-chemical-imbalance-in-the-brain

Pharmakeia

https://www.etymonline.com/search?q=pharmakeia&type=0
There is a principle which is a bar against all information, which cannot fail to keep a man in everlasting ignorance. That principle is contempt prior to investigation. - Herbert Spencer

KiwiGriff

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Re: Human Stupidity (Human Mental Illness)
« Reply #413 on: January 22, 2024, 04:11:04 AM »
<edit Neven: This is off-topic to the thread, but not to the forum, so I'll let it pass>

Quote
iow Climate Science is less reliable than Medical Science. AT least in medical science you can see and touch things and measure things fairly accurately and reliably.


This is climate change denial Neven .
Your pets have no idea about science, statistics or critical thinking.... at all.


Observed annual global temperature, unadjusted (pink) and adjusted for short-term variations due to solar variability, volcanoes and ENSO (red) as in Foster and Rahmstorf (2011).  12-month running averages are shown as well as linear trend lines, and compared to the scenarios of the IPCC (blue range and lines from the 2001 report, green from the 2007 report).  Projections are aligned in the graph so that they start (in 1990 and 2000, respectively) on the linear trend line of the (adjusted) observational data.
https://skepticalscience.com/ipcc-scientific-consensus-intermediate.htm
« Last Edit: January 22, 2024, 09:27:07 AM by Neven »
Animals can be driven crazy by placing too many in too small a pen. Homo sapiens is the only animal that voluntarily does this to himself.
Notebooks of Lazarus Long.
Robert Heinlein.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #414 on: January 22, 2024, 04:20:09 AM »
Being Poor Doesn't Have the Same Effect as Living in Chaos

The question of poverty vs. instability

This piece titled “Throwaway Kids” reports researchers surveyed “nearly 6,000 inmates in 12 states — representing every region of the country — to determine how many had been in foster care and what effect it had on their lives. Of the inmates who took the survey, 1 in 4 said they were the product of foster care. Some spent the majority of their childhood in strangers’ homes, racking up more placements than birthdays.”

In the Los Angeles county foster care system (my beloved alma mater), only 64.5% of foster kids graduate from high school. Maybe not so surprising.

Here’s something more surprising. According to the same report from LA county, the overall high school graduation rate in LA is 86.6%.

And the graduation rate for students categorized as “socioeconomically disadvantaged” is also 86.6%. Poor kids graduate at the same rate as everyone else.

The gap between poor kids and foster kids exists nationwide, too.

72.4% of kids across the U.S. in the lowest socioeconomic quintile graduate from high school. In contrast, nationwide, only 58% of foster kids graduate from high school.

What about college? 11% of kids in the bottom socioeconomic quintile graduate from college. For foster kids: 3%.

Incarceration rates are similar. About 8% of males from families in the bottom socioeconomic quintile do time in prison or jail. For males who were in foster care: 60%

Consider that to become foster parents, people must meet a minimum economic threshold. They can’t be poor.

Which means kids in foster care are not in as materially impoverished an environment as kids in the bottom income quintile.

So what explains the gap in graduation and incarceration rates between foster kids and poor kids?

One reason worth highlighting comes from this widely-cited paper in Developmental Psychology titled, “Evolution, Stress, and Sensitive Periods: The Influence of Unpredictability in Early Versus Late Childhood on Sex and Risky Behavior.”

The researchers used a longitudinal data set. In the 1970s, women at a public health clinic agreed to respond to questions that tracked both themselves and their then unborn children.

Both the mothers and, later, their children, responded to questionnaires at multiple time points until the children reached early adulthood.

The researchers were interested in how 2 different environmental factors affected 5 key variables.

One environmental factor was the amount of environmental harshness children experienced before age 5.

Researchers measured environmental harshness by the mother’s socioeconomic status, occupational prestige, and household income. How materially comfortable was the kid?

The other environmental factor was the amount of environmental unpredictability children experienced before age 5.

The researchers measured environmental unpredictability by number of changes in residence (e.g., moving to a different house/apartment), changes in cohabitation status (e.g., whether and how often male romantic partners moved in or out of the house/apartment), and changes in employment status.

In short, how often the kid moved, how frequently the adults in the kid’s life appeared and disappeared, and how frequently his mom changed jobs. How chaotic was the kid’s life?

And the researchers wanted to know how these two factors influenced 5 outcome variables:

    Age at first intercourse

    Number of lifetime sexual partners at age 23

    Criminal acts

    Aggression (e.g., “I deliberately try to hurt others,” “I destroy things belonging to others”)

    Delinquency (frequency of lying/cheating, breaking rules, setting fires, stealing, drug use)

Researchers found that childhood poverty (harshness) was not significantly associated with any of the 5 outcome variables.

In contrast, there was a significant correlation between childhood unpredictability 4 of the 5 outcome variables—number of sexual partners, aggressive behavior, delinquent behavior, and criminal behavior. For males, but not females, instability predicted having sex at an earlier age.

The correlation between unpredictability in childhood and criminal behavior in adulthood was particularly striking (r = .40, p < .01). This effect size is equivalent to the correlation between socioeconomic status and SAT scores.
(more)

https://www.robkhenderson.com/p/being-poor-doesnt-have-the-same-effect

https://www.kansascity.com/news/special-reports/article238206754.html

Neven

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Re: Human Stupidity (Human Mental Illness)
« Reply #415 on: January 22, 2024, 09:33:27 AM »
This is climate change denial Neven .
Your pets have no idea about science, statistics or critical thinking.... at all.

Saying climate science isn't 100% reliable, is not the same as climate change denial. Nevertheless, I disagree that climate science is more unreliable than medical science. I believe the human body is even more complicated than the climate, if only for the fact that there are mental and spiritual components that are entirely overlooked by medical science. At face value, I would say that the climate is more of a machine than the human body (if I'm wrong, I pray Gaia will forgive me).

And as Sean says, there is not just one body, but several types.

As for stupidity, I'm of the opinion that all people are stupid, the only difference being that some are aware of it, and others aren't. And that wisdom trumps intelligence and knowledge every day.
The enemy is within
Don't confuse me with him

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KiwiGriff

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Re: Human Stupidity (Human Mental Illness)
« Reply #416 on: January 23, 2024, 03:56:31 AM »
Quote
iow Climate Science is less reliable than Medical Science. AT least in medical science you can see and touch things and measure things fairly accurately and reliably.
No Neven this is both denial and ignorance.
Coming on this website and pushing such bullshite among a cohort that have an interest in  the phenomenon some most of us have been looking into global warming  for decades  shows a deluded individual who has no fuckin idea about what he is saying ... Human stupidity writ large.
Modern measurement's of global temperature are extremely accurate due to the power of large numbers .
We can also measure  the absorption spectra of greenhouse gasses to a high degree of accuracy
The rest is based on  math which by definition is proof .
 S Arrhenius in 1896  quantified the effect of increasing CO2 before long before we even discovered penicillin .
. https://www.rsc.org/images/Arrhenius1896_tcm18-173546.pdf
As to depression.
it is far more complex than give someone drugs and cure it .Drugs mask the symptoms not resolve the root cause. Many find some form of counselling helpful.
You certainly can not measure depression as it is subjective experience at an individual level.
 
Animals can be driven crazy by placing too many in too small a pen. Homo sapiens is the only animal that voluntarily does this to himself.
Notebooks of Lazarus Long.
Robert Heinlein.

gerontocrat

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Re: Human Stupidity (Human Mental Illness)
« Reply #417 on: January 23, 2024, 12:31:36 PM »
Isn't one automatically an anti-vaxxer when criticising Big Pharma?
I don't think so.

My mother nearly died of measles in the 1920's.
My mother-in-law nearly died of the 'flu at the end of World War I.
I am glad I had the Tuberculosis dose when I was a boy. My Dad's first wife died of TB in the late 1930's, and it was still around in the UK in the 1950s and 1960s.
I am glad I had the polio dose when I was a boy. At our small primary school there were two boys limping around with metal cages around their legs.
I was glad the Rabies vaccine existed when I was living in the bush in a part of Africa where Rabies was endemic.

That is not a vote for Big Pharma, which in common with Big Oil & Gas, has purchased enough politicians to make a mockery of us. We know, for example, that the overuse of antibiotics, perhaps especially in agriculture, has been a driver of antibiotic resistance in new varieties of pathogens, and Big Pharma has promoted and encouraged that overuse, and the regulators are conspicuous by their absence.

And as for pesticides & herbicides..........

No, Big Pharma deserves our hate. Their perversion of science for profit is disgusting.
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SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #418 on: January 24, 2024, 03:41:15 AM »
This is climate change denial Neven .
Your pets have no idea about science, statistics or critical thinking.... at all.

Saying climate science isn't 100% reliable, is not the same as climate change denial. Nevertheless, I disagree that climate science is more unreliable than medical science. I believe the human body is even more complicated than the climate, if only for the fact that there are mental and spiritual components that are entirely overlooked by medical science.

At face value, I would say that the climate is more of a machine than the human body (if I'm wrong, I pray Gaia will forgive me).

And as Sean says, there is not just one body, but several types.

As for stupidity, I'm of the opinion that all people are stupid, the only difference being that some are aware of it, and others aren't. And that wisdom trumps intelligence and knowledge every day.

And they all trump Data!

coincidentally I was only looking into this issue recently eg
https://digitalcommons.andrews.edu/cgi/viewcontent.cgi?params=/context/pubs/article/2175/&path_info=Wisdom_Hierarchy_Goes_to_Seminary.pdf

Gaia never forgives Neven. She dispenses Justice like the Kali Goddess dispenses karma. :)

It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

The Walrus

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Re: Human Stupidity (Human Mental Illness)
« Reply #419 on: January 24, 2024, 03:08:57 PM »
Quote
iow Climate Science is less reliable than Medical Science. AT least in medical science you can see and touch things and measure things fairly accurately and reliably.
No Neven this is both denial and ignorance.
Coming on this website and pushing such bullshite among a cohort that have an interest in  the phenomenon some most of us have been looking into global warming  for decades  shows a deluded individual who has no fuckin idea about what he is saying ... Human stupidity writ large.
Modern measurement's of global temperature are extremely accurate due to the power of large numbers .
We can also measure  the absorption spectra of greenhouse gasses to a high degree of accuracy
The rest is based on  math which by definition is proof .
 S Arrhenius in 1896  quantified the effect of increasing CO2 before long before we even discovered penicillin .
. https://www.rsc.org/images/Arrhenius1896_tcm18-173546.pdf
As to depression.
it is far more complex than give someone drugs and cure it .Drugs mask the symptoms not resolve the root cause. Many find some form of counselling helpful.
You certainly can not measure depression as it is subjective experience at an individual level.
 

It is neither denial nor ignorance.  I would argue that we can measure the average temperature of the human body more accurately than that of the planet Earth. 

He is not talking about measurements, but consequences.  When the temperature of the human body deviates from the average, we know [to a high degree of certainty] the consequences.  The Earth, less so.  Yes, the human body is a complex organism.  But so is the Earth.  We have difficulty ascertaining the consequences on agriculture; some areas will be wetter, others drier, and the temperature change is not uniform.  We are scratching our heads to try to understand why the Arctic sea ice has not decreased during the most recent temperature increases.

I believe that your comments are misguided and insulting.  You owe Neven an apology.

Neven

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Re: Human Stupidity (Human Mental Illness)
« Reply #420 on: January 24, 2024, 04:15:51 PM »
I believe that your comments are misguided and insulting.  You owe Neven an apology.

No need. It's just a misunderstanding and divergence of opinion/definition.
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AbruptSLR

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Re: Human Stupidity (Human Mental Illness)
« Reply #421 on: January 28, 2024, 04:23:36 PM »
I believe that your comments are misguided and insulting.  You owe Neven an apology.

No need. It's just a misunderstanding and divergence of opinion/definition.

I note that in the linked YouTube video that Sabine Hossenfelder states that it is her opinion about how stupid it is that the IPCC has downgraded the projections of 'Hot Climate Change Models', when calculating their projections of the probable range for ECS.


« Last Edit: January 28, 2024, 05:43:15 PM by AbruptSLR »
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SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #422 on: January 30, 2024, 12:38:32 PM »
^^^^^^^^^^^^  Great video presentation - worth watching and seriously thinking about what she is saying, because she is far from alone on this warning.

In other news   Ep. 6 | Mann's Money Climate Change on Trial

Professor Michael Mann continues to give evidence in his 12 year old Defamation Court Case against writer Mark Steyn and scientist Rand Simberg in DC .

Audio @29:40 mins admitted facts not in dispute stated by the Judge - Michael Mann writes on Twitter --
(quote)  "People with contrary views on climate science are ..."
- "Hired guns"
- "Tin foil hat wearing conspiracy theory mongers"
- "Climate deniers"
- "Horrible human beings"
- "Cowardly trolls"
- "Misogynistic ogre"


If you come a cropper with Professor Michael Mann, or for just disagreeing with him, this is what you're going to be called all kinds of ad hominem names and ridiculed publicly.

Maybe this is why Mann's Grants level went down - and it had nothing to do with Steyn or Simberg had said about him. Maybe people simply found Mann utterly distasteful as a human being and no longer wanted to Fund his research?

@ 34 mins
Next in an email to Gavin Schmidt and another fellow 'climate scientist' Michael Mann is found to write the following about Steve McIntyre : Let's see how Mr Deeply Sensitive Easily Offended Michael speaks about other scientists
- "Ugly behaviour from that human filth we call McIntyre ..... the asshole has everything he needs to be able to do an analyses himself apparently too lazy or too stupid to do it ..."

---------------------

Listen as Professor Mann claims he suffered financial damage, and was treated like a pariah after the articles came out. Among the indignities were mean looks from people in supermarkets

However, Simberg’s lawyer used Mann’s own career evaluations to show his career and income had improved since the articles were published. She made the case that he suffered no damage. She had Mann describe his glamorous life in recent years with trips to the UK, Canada, Iceland, Ireland, and Austria. Then we follow him to film festivals and book tours in between partying with Bill Clinton and Leonardo DiCaprio.

And stay tuned to the end for bombshell revelation about who is funding Michael Mann’s 12-year legal odyssey.

https://podcasts.apple.com/us/podcast/ep-6-manns-money/id1713827256?i=1000642922089 

It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #423 on: February 07, 2024, 10:15:31 AM »
Western, Educated, Industrialised, Rich, Democratic.

What do W.E.I.R.D countries have in common? 

The citizens of these countries exhibit markedly more extreme psychological characteristics than those of non-WEIRD nations.

One of the weirdest characteristics is a belief in a fixed “self’ which will behave in a reliable and predictable manner no matter the environment. The belief in this unchanging self is what makes it very difficult for us to change our minds—and even concoct wild rationalisations to justify our behaviour.

Welcome to the age of cognitive dissonance.

Sarah Stein Lubrano, a researcher at Oxford University, joins me to explain the cognitive dissonance phenomenon, its roots in the alleged security granted to us by a fixed sense of self, and why it’s so hard to change our beliefs. She then reveals what neurophilosophy tells us about how to help others change our minds, the power of storytelling, and the importance of social infrastructure for creating cohesive, fluid and non-judgemental communities. It is these brave communities which dare examine themselves, their beliefs about the world—and change their maladaptive behaviours. This is an episode about how to dare change our minds.

Why is the world in crisis?


It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #424 on: February 10, 2024, 01:04:39 AM »
Fitness trackers find new symptom of depression -- body temperature

(...)
Over the course of seven months, the participants submitted their vital signs collected by the ring and stored in a phone app, and also self-reported their emotions and mental health in daily surveys.

Could the ring predict COVID-19? Yes, the researchers found. The ring picked up signs the participants may have been infected on average 2.75 days before they tested positive, according to the study.

But that wasn’t the only data that stood out to the research team.

The study found that participants with higher body temperatures also reported higher rates of depressive symptoms and feelings of depression using temperatures taken while users were awake.

“Specifically, these analyses replicated prior results showing that daytime self-reported body temperature was associated with greater depressive symptoms and build on one prior study showing that the asleep-awake body temperature difference was more than twice as large among controls relative to individuals with depression,” the researchers said in the study.

While it’s not clear if poor body temperature regulation is a symptom of depression or vice versa, the researchers said people with depression overall had a change to their natural immune-based feedback system.

This means that while other people go through natural temperature cycles throughout the day and over time, people experiencing depression were not, and found it harder to self-cool their bodies, according to the study.

It could be a way in for non-pharmaceutical treatment.

“Ironically, heating people up actually can lead to rebound body temperature lowering that lasts longer than simply cooling people down directly, as through an ice bath,” lead author Ashley Mason said in a news release. “What is we can track the body temperature of people with depression to time heat-based treatments well?”

Mason said there is an existing small body of research that suggests putting people in hot tubs or saunas can trigger the body to self-cool, causing them to sweat. If thermoregulation is a symptom of depression, as the Oura Ring study suggests, temperature treatment could be an effective way to treat depression.

“To our knowledge, this is the largest study to date to examine the association between body temperature — assessed using both self-report methods and wearable sensors — and depressive symptoms in a geographically broad sample,” Mason said. “Given the climbing rates of depression in the United States, we’re excited by the possibilities of a new avenue of treatment.”

The rising popularity of fitness trackers may also help more people identify symptoms of depression.
(more)

https://www.arcamax.com/healthandspirit/health/healthtips/s-3105956?fs

AbruptSLR

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Re: Human Stupidity (Human Mental Illness)
« Reply #425 on: February 12, 2024, 05:57:15 PM »
^^^^^^^^^^^^  Great video presentation - worth watching and seriously thinking about what she is saying, because she is far from alone on this warning.

...
Here is Sabine's follow-up video on the same topic:

Title: "Climate Plans Potentially Dangerous, New Study Says"

“It is not the strongest or the most intelligent who will survive but those who can best manage change.”
― Leon C. Megginson

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #426 on: February 13, 2024, 09:22:43 AM »
snip

You're the best A SLR. Loved your daily education service years ago here. Best wishes to you. Well done!
It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #427 on: February 18, 2024, 02:53:43 AM »
Most People With Addiction Simply Grow Out of It. Why Is This Widely Denied?

The idea that addiction is typically a chronic, progressive disease that requires treatment is false, the evidence shows. Yet the "aging out" experience of the majority is ignored by treatment providers and journalists.

When I stopped shooting coke and heroin, I was 23. I had no life outside of my addiction. I was facing serious drug charges and I weighed 85 pounds, after months of injecting, often dozens of times a day.

But although I got treatment, I quit at around the age when, according to large epidemiological studies, most people who have diagnosable addiction problems do so—without treatment. The early to mid-20s is also the period when the prefrontal cortex—the part of the brain responsible for good judgment and self-restraint—finally reaches maturity.

According to the American Society of Addiction Medicine, addiction is “a primary, chronic disease of brain reward, motivation, memory, and related circuitry.” However, that’s not what the epidemiology of the disorder suggests. By age 35, half of all people who qualified for active alcoholism or addiction diagnoses during their teens and 20s no longer do, according to a study of over 42,000 Americans in a sample designed to represent the adult population.
Only a quarter of people who recover have ever sought assistance in doing so (including via 12-step programs). This actually makes addictions the psychiatric disorder with the highest odds of recovery.

The average cocaine addiction lasts four years, the average marijuana addiction lasts six years, and the average alcohol addiction is resolved within 15 years. Heroin addictions tend to last as long as alcoholism, but prescription opioid problems, on average, last five years. In these large samples, which are drawn from the general population, only a quarter of people who recover have ever sought assistance in doing so (including via 12-step programs). This actually makes addictions the psychiatric disorder with the highest odds of recovery.

While some addictions clearly do take a chronic course, this data, which replicates earlier research, suggests that many do not. And this remains true even for people like me, who have used drugs in such high, frequent doses and in such a compulsive fashion that it is hard to argue that we “weren’t really addicted.” I don’t know many non-addicts who shoot up 40 times a day, get suspended from college for dealing, and spend several months in a methadone program.

Moreover, if addiction were truly a progressive disease, the data should show that the odds of quitting get worse over time. In fact, they remain the same on an annual basis, which means that as people get older, a higher and higher percentage wind up in recovery. If your addiction really is “doing push-ups” while you sit in AA meetings, it should get harder, not easier, to quit over time. (This is not an argument in favor of relapsing; it simply means that your odds of recovery actually get better with age!)
(more)

https://psmag.com/social-justice/people-addiction-simply-grow-widely-denied-91605

AbruptSLR

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Re: Human Stupidity (Human Mental Illness)
« Reply #428 on: February 28, 2024, 08:01:15 PM »
snip

You're the best A SLR. Loved your daily education service years ago here. Best wishes to you. Well done!

Sabine has another follow-up video about climate sensitivity that is worth watching:



“It is not the strongest or the most intelligent who will survive but those who can best manage change.”
― Leon C. Megginson

SeanAU

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Re: Human Stupidity (Human Mental Illness)
« Reply #429 on: February 29, 2024, 01:43:24 AM »
snip

You're the best A SLR. Loved your daily education service years ago here. Best wishes to you. Well done!

Sabine has another follow-up video about climate sensitivity that is worth watching:



Yes, zenith shared it elsewhere, and I added in some of the transcript.

https://forum.arctic-sea-ice.net/index.php/topic,3535.msg395695.html#msg395695

She's very clear and very good. the blind confirmation bias of celebrity climate scientists is clear.

Here's another example of that with Gavin Schmidt over last years temps and "models"

from 4 mins .... @6:30 mins "total failure" .... then watch how distorted and childish it quickly becomes


It's wealth, constantly seeking more wealth, to better seek still more wealth. Building wealth off of destruction. That's what's consuming the world. And is driving humans crazy at the same time.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #430 on: March 06, 2024, 07:58:06 AM »
The Self-Administered Gerocognitive Exam (SAGE) is designed to detect early signs of cognitive, memory or thinking impairments. It evaluates your thinking abilities and helps physicians to know how well your brain is working.

https://wexnermedical.osu.edu/brain-spine-neuro/memory-disorders/sage

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #431 on: March 06, 2024, 10:05:26 AM »
Everyone knows politics makes people crazy. But what kind of crazy? Which page of the DSM is it on?

I’m only half joking. Psychiatrists have spent decades developing a whole catalog of ways brains can go wrong. Politics makes people’s brains go wrong. Shouldn’t it be in the catalog? Wouldn’t it be weird if 21st century political extremists had discovered a totally new form of mental dysfunction, unrelated even by analogy to all the forms that had come before?
(snip)
In any other situation, a condition with impaired cognition, psychotic symptoms, emotional instability that impaired normal functioning, and associated addictions/obsessions would qualify as a mental disorder. So again, which mental disorder is it?

This post is about the possibility that it might be trauma.
(snip)
When I say that politics is analogous to trauma, I mean that decades of consuming news favoring your chosen side, learning its arguments, learning the approved counterarguments to the other side’s points, and hearing about the outrages perpetrated by your enemies - have trapped both the relevant cognitive and emotional priors: you are absolutely sure your side is right, and you feel such intense negative emotion about the other side that it makes it impossible to interpret anything they say fairly.
(snip)
In that post, I speculated that trapped priors might be responsible for some of the cognitive symptoms of political hyperpartisanship. But trapped priors have both cognitive and emotional manifestations, and I’m starting to think that they might just explain the whole picture. I think the easiest way to express this concept for public consumption is “political hyperpartisanship is a form of trauma.”
VII.

Is this actually a good way to express a concept for public consumption?

I’m nervous about the creeping expansion of “trauma”. On the one hand, it’s good that people who feel traumatized by things can have access to trauma-related resources and have other people respect/validate their suffering. On the other, it might be dangerous to create an expectation of traumatic consequences for minor wrongs.

Ancient warriors apparently didn’t get PTSD. Everything about this claim is still controversial, but the explanation that makes the most sense to me is that they had a narrative in which war was heroic and inspiring, not traumatizing. I think this story is backed up by cross-cultural comparisons and research on depression: thinking you’re supposed to feel traumatized is a risk factor for problematic trauma symptoms.

So this theory is dangerous even if it’s true: it might make people feel more triggered by political disagreements and less able to laugh them off. On the other hand, I don’t really see a lot of people laughing off political disagreements now. Maybe we’ve already maxed our our ability to feel traumatized by political stimuli?

This is a strong claim, but I make it in the context of the whole political ecosystem. Suppose that outrage addiction is, in fact, trauma addiction. That means the media ecosystem is a giant machine trying to traumatize as many people as possible in order to create repeat customers, ie trauma addicts. Combine that with the explicit, confessed desire on both sides to “trigger” the other as much as possible, and you have a lot of very clever people all trying to maximize one another’s trauma levels. On the external level, that looks like weaving as strong a narrative of threat and persecution as possible and trying to hit people in their psychological weak points. On the internal level, it means making sure they replace their normal ability to update with a series of triggers that make them replace reality with pre-packaged stories about how the other side is innately evil and everything they do is for specific threatening and evil reasons. Once you have a machine like that running, I’m not sure that identifying it will make things too much worse.

But thinking of things this way has made me less interested in consuming this kind of media, and I hope it does the same for you.

https://www.astralcodexten.com/p/the-psychopolitics-of-trauma

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #432 on: March 11, 2024, 09:42:27 AM »
Ego tripping: Why do psychedelics "enlighten" some people — and make others giant narcissists?

Psychedelics have a reputation for humbling people, but "hallucinogenic elitism" is also common. What gives?

(...)
In the book he recounts being invited to an exclusive gathering of business elites. The gathering was spawned by a duo who had a powerful ayahuasca experience and felt it their purpose to bring together like-minded leaders to address problems of climate change. A Zen monk was present at the gathering to help oversee things, and after a few hours of small talk the cohort got down to brass tacks. They were the self-anointed ones who were going to save the world.

“How could this awakening group of elites now lead humanity to a greener, more cooperative future?” Rushkoff wrote. “Lead? Really? These were freshly-minted New Agers whose entire life experience had been spent as financial advisors, brand managers or tech investors. Now, thirty minutes into their awakened selves, they were ready to lead the revolution.”

According to Rushkoff, for these people, psychedelics seemed to simply garnish their pre-existing capitalist beliefs with a newfound cosmic justification. All their systems of exploitation and domination held strong, and psychedelics just amplified a sense that they were the only ones that could save the world.

“There's [a-hole] capitalists having intense psychedelic experiences, blowing their f**king brains out, but still processing the experiences in such a way as to reinforce the worst of themselves,” Rushkoff said in an interview with Salon.

The phenomenon of these billionaires consuming brain-blasting doses of psychedelics and not being shaken and humbled is one that still flummoxes Rushkoff. He sees this as both a problem of set and setting — powerful people who consider themselves leaders and are surrounded by lackeys who never say no —  and a fundamental indication that some people’s brains are just wired differently.

“There is a feedback loop quality to some psychedelics,” Rushkoff explained. “It can loop where you become a more strident version of yourself. So you know, Elon Musk on psychedelics is even more Elon Musk than Elon Musk.”

When talking about the way the über-rich take psychedelics and come back with a heightened elitism, Rushkoff is very clear. These people are not neurotypical. Their brains are wired differently, he says. If your view on reality is one of a systems theorist, then your psychedelic experience will simply amplify that perspective. Combine the idea that reality is something to be “fixed” with a sense of embedded power — suggesting you are the one to fix it — and you’re getting close to a perfect recipe for entering the echelons of the hallucinogenic elite.

We are God... Or I am God?

(more)

https://www.salon.com/2024/03/08/ego-tripping-why-do-psychedelics-enlighten-some-people--and-make-others-giant-narcissists/

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #433 on: March 15, 2024, 08:53:15 PM »
Molecular Alterations in Brain Tissue Provide Clues to Suicidal Ideation

(...)
Key Facts:

    The study highlights molecular alterations in suicide victims, suggesting new pathways for understanding and preventing suicidal behavior.
    Researchers emphasized the role of the prefrontal cortex in behavioral control, noting its relevance in the context of young people’s susceptibility to suicide.
    Molecular findings include changes in neurotransmitters and transcription factors, pointing to potential targets for antidepressants and other treatments.
(snip)
When the data collected in the literature review was fed into an algorithm, it was possible to identify biological mechanisms and pathways associated with suicide. Alterations to inhibitory neurotransmitters were among the main changes observed.

“Molecular alterations were associated above all with glial cells, such as astrocytes and microglia, which interact closely and dynamically with neurons and are fundamental to control of cellular communication, metabolism and plasticity,” Martins-de-Souza said.

The analysis also pointed to alterations to certain transcription factors (molecules responsible for regulating the expression of several genes).

“These included transcription factor CREB1, which has already been widely studied for its effects on neuroplasticity and as an important target for antidepressants. However, transcription factors MBNL1, U2AF and ZEB2, which are associated with RNA splicing, formation of cortical connections and gliogenesis, have never been studied in the context of depression and suicide,” he said.

https://neurosciencenews.com/genetics-brain-tissue-suicide-25761/


Depicting the molecular features of suicidal behavior: a review from an “omics” perspective

https://www.sciencedirect.com/science/article/abs/pii/S0165178123006327


Highlights

    •

    GABAergic and glutamatergic neurotransmissions are associated with suicide behavior.
    •

    Astrocytes, oligodendrocytes, and microglia are dysregulated in suicidal behavior.
    •

    Energy and inflammatory metabolism pathways are dysregulated in suicidal behavior.
    •

    Imbalanced lipid transport and metabolism associated with suicide behavior.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #434 on: March 24, 2024, 08:30:13 PM »
(gonna post this whole article here, in case it dissapears off the web in future. )

How To Choose A Romantic Partner
What psychology tells us about the pillars of a joyful life

Below is a piece on mating psychology I wrote for Onn Health. It is aimed primarily at (heterosexual) men, yet the insights offered here are broadly applicable to everyone.

The two most powerful predictors of happiness and life satisfaction are working in the right profession and finding the right spouse.

You can commit a lot of blunders in your life, but if you manage to get two things right, you will maximize your chance of long-term wellbeing.

Our choice of job and our choice of spouse are central to our happiness because they are where we spend most of our lives—at work and with our families. Therefore, we should devote a good deal of time concentrating on how to make the best possible decision for these two sources of potential happiness. Indeed, making the wrong choice can lead to potential misery.

Interestingly, much of modern advice prioritizes education and career, often relegating relationships to a secondary concern or valuing them primarily for their potential to enhance career ambitions.

Relationships, though, are critical for our health and wellbeing. Studies have found that the effect of poor relationship quality on mortality is as strong as the effects of better-known risk factors, such as smoking and alcohol use, and even stronger than other important factors, such as sedentariness and obesity.

For those who are focused on their careers, choosing the right partner can fuel occupational success. For instance, people with conscientious romantic partners tend to report higher job satisfaction and income, and are more likely to be promoted. This pattern held even after controlling for the study participants’ own conscientiousness. A disciplined and hard-working romantic partner can help us succeed in our own careers.

Indeed, there are examples of well-known men and the women who have helped them in their journeys:

Mr Beast:

    “I have someone who I think is very beautiful, very intelligent, makes me better, is constantly pushing me, is okay with me working hard, makes me smarter. And just all these different things. For me, love just makes me a better person.”

Connor McGregor:

    “My girlfriend worked very hard throughout the years and stuck by me when I had essentially absolutely nothing. I only had a dream that I was telling her.”

Chris Bumstead:

    “She just built this confidence in me… It was a really important moment for my personal growth, champion growth, relationship growth.”

Warren Buffett:

    “Susie really put me together. She believed in me. She got me to believe in myself, and that changed my life.”

    “And I would not only have not turned out to be the person I turned out to be, but I actually wouldn’t have been as successful in business without that. She made me more of a whole person.”

These examples show only one side of the story. In healthy relationships, both partners are expected to receive net benefits and grow.

Research in evolutionary and social psychology has illuminated key findings that help us to understand how people choose mates, as well as the factors that predict relationship success.

George Vaillant, former director of the multigenerational Harvard Study of Adult Development, has noted that “warm, intimate relationships are the most important prologue to a good life.”

Warm relationships supply benefits to both happiness and health.

How do people go about choosing mates? In popular culture, we often hear two different adages when it comes to relationship formation: Opposites attract, and birds of a feather flock together.

The former might make for a good romantic comedy. But in the real world, people tend to mate assortatively. We generally favor romantic partners who are similar to ourselves.

This is especially true for education and intelligence. In the U.S., for example, if your highest level of education is a high school diploma, your probability of marrying a college graduate is only nine percent. In contrast, if you hold a college degree, your probability of marrying a fellow college graduate is sixty-five percent. Interestingly, though, couples’ similarity in intelligence does not seem to predict relationship satisfaction.

Beyond education, we also tend to choose romantic partners who are similar to ourselves in terms of age, political orientation, religious affiliation, and socioeconomic status.

Does similarity predict stronger relationship satisfaction? The answer seems to be no. A meta-analysis concluded that “similarity had very little effect on satisfaction.” This doesn’t mean, of course, that similarity is meaningless for romantic satisfaction. More likely, similarity is necessary but not sufficient for romantic satisfaction. That is, while similarity does not guarantee relationship satisfaction, strong dissimilarities might be “deal-breakers” that would contribute to discontent. Your romantic partner holding the same political beliefs as you doesn’t necessarily mean you’ll be 100% satisfied with each other; but if they take the opposite stance on every view you hold, there’s a strong chance that relationship wouldn’t last very long.

So what does predict relationship satisfaction?

One factor seems to be authenticity. A team of psychologists found that the link between authenticity in relationships and relationship satisfaction is very strong. For instance, people who strongly agreed with statements such as “I share my deepest thoughts with my partner even if there’s a chance he/she won’t understand them” reported being particularly happy in their relationships. Interestingly, the study found that authentic people tended to mate with other authentic people, whereas deceptive individuals tend to attract deceptive partners. This seems to be another example of assortative mating, whereby people find themselves in relationships with partners similar to themselves.

What else besides authenticity predicts relationship satisfaction? A 2016 paper in Evolution and Human Behavior, authored by Daniel Conroy-Beam, Cari D. Goetz, and David Buss explored what makes people happy in their relationships. They discovered that people were less satisfied in relationships when their partners were less desirable compared to other potential choices. However, this was specifically the case for individuals who were more attractive than their partners. That is, people were satisfied with mates who were either more attractive than themselves, or more attractive than alternative choices. In short, when people were with partners who were attractive and hard to replace, then they were more likely to be satisfied. It seems that people aren’t asking themselves, “Does my partner fulfill my relationship needs?” Rather, they ask “Is my partner better than the realistic alternatives?” We aren’t gauging on some objective rubric. Rather, we grade our partners on a curve, comparing them to others we could reasonably hope to pair with.

This gets to the question of how we should approach searching for a compatible mate. An important idea from decision theory that can assist with this is known as the 37% rule, or “the secretary problem.” Suppose you’re looking for the best candidate for a secretary position (or any other job). The rule says that you should estimate how many total applicants are likely to seek the position, interview the first 37 percent of them, and remember the best out of that initial sample. Then, continue interviewing until you find a candidate who is even better than that. Once you find that better candidate, hire him or her. That is how you select the optimal candidate.

The problem with this rule is that it takes a lot of time and energy, especially if you are faced with a large number of possible candidates. You can’t realistically date 37% of all women you might possibly be interested in, and then keep going until you find someone more compatible than the best in that batch. However, researchers have found that a similar rule called “Try a Dozen” can work just as well as the 37% rule. According to this simpler approach, you would date a dozen possible romantic partners, remember the best of them, and then pick the very next prospect who is even more appealing to you. Of course, this is just a theoretical model that sheds light on the challenges of trying to optimize a difficult decision. It has many shortcomings and is not necessarily applicable to all individuals in all circumstances.

Many men try to get the hottest possible partner they can find. But this can present its own problems. As David Buss has said, “Mates, once gained, must be retained.” An average guy might manage to get a few dates with a supermodel. But the supermodel’s array of potential alternative options can introduce potential instability into the relationship. This can lead to jealousy, increased mate guarding, warding off potential romantic rivals, increased stress, heated arguments, and so on.

Of course, the reverse is not ideal. Entering a relationship with someone who is noticeably less attractive than you can give rise to dissatisfaction, conflict, and a wandering eye as you consider possible alternatives. The ideal situation, as Buss says, is “when both people feel lucky to be with the other person.” Of course, if your current pool of mates you could reasonably hope to attain is less attractive than you’d like, there is a simple option: Become more attractive yourself. For appearance, keep up on personal grooming and hygiene; improve your health and fitness; buy clothes that are stylish and fit well; get a good haircut. As a man, you can also level up your attractiveness by earning a promotion at work, switching to a higher paying position, or seeking a cool side job (bartenders, musicians, and volunteer firefighters don’t get paid like surgeons but still appeal to many women).

Many people have noticed that young people are unrealistically expected to know what career they will pursue at the age of 18 or 22. Seldom does anyone point out that the same logic applies to long-term romantic commitment. Interestingly, while there is a lot of guidance for how to choose a good career, far less support is available for choosing the right spouse.

Choosing a mate is not just choosing a mate. It’s also casting a vote for who you will be and who your children will be. The psychologist and relationship researcher Eli Finkel has pioneered the concept of the Michelangelo phenomenon. “In Michelangelo’s mind,” Finkel writes, “the David existed within the rock before sculpting began.” The idea is that in healthy marriages, each partner helps foster the other’s best self.

Mate choice also profoundly influences children. If you have kids, your partner’s genetics will significantly influence their intelligence (at least 60% heritable), personality traits (more than 40% heritable), and mental health (more than 30% heritable). And as I cover extensively in my book, healthy, stable relationships benefit children. Having a partner who contributes to such a relationship will be instrumental in your child’s development and wellbeing.

Given the importance of marriage in a man’s life, it is crucial to choose a compatible spouse. Knowing which qualities to avoid and which to seek out can save you from future emotional and perhaps financial ruin.

People often focus on attributes they would like in a partner, but it is perhaps even more important to know which characteristics to avoid. “Red flags,” in common parlance.

In his book Gatekeeper: The Tactical Guide to Commitment, the psychologist Shawn T. Smith offers several characteristics to watch out for. Here are a few important ones:

    ·  Shifting responsibility for managing emotions. Rather than speak directly about their own sadness or anger, someone might redirect the conversation onto their partners by saying things like “Why did you need to do that?” Or “Only someone with problems would say it that way.” These ad hominem attacks imply that they are not responsible for their own feelings, and that you are to blame for managing their emotions. Relatedly, David Buss has suggested that one desirable feature for any potential mate is how quickly they return to their emotional baseline. That is, if your partner is angry or upset with you, do they take a long time to settle down? Do their negative emotions take a long time to subside? This is a key marker of emotional stability (neuroticism). Low emotional stability (high neuroticism) is consistently associated with increased conflict, marital dissatisfaction, and risk of divorce.

    ·  Forcing you to play the guessing game. Instead of stating their needs outright, someone might say, “If you cared about me, you would know what I need.” This puts you in a state of constant uncertainty, a recipe for an unhappy relationship. In fact, personally, I would recommend a policy of overcommunication. For uncertainties and ambiguities, try to cultivate a rule where both you and your partner err on the side of saying more than you think is necessary, to the point where you and your partner say things to each other that seem perfectly obvious. This can save a lot of heartache.

    ·  Character assault. Statements like “You always do that” or “You never listen” indicate an undeveloped personality and suggest that the person is unwilling to bear any share of responsibility for conflicts that arise.

    ·  The silent treatment. Evolutionary psychology research suggests that anger evolved in order to bargain for better treatment. It can be expressed in one of two ways. First, inflicting costs, which can entail verbal or physical abuse. Second, anger can be expressed by withholding benefits which can entail tactics like the silent treatment. Both are intended to manipulate the target’s behavior. However, we have rightly developed a norm against overt anger expressions (inflicting costs). Such a norm would also be helpful for covert anger expressions as well (withholding benefits). Healthy communication rather than yelling or snubbing is a better approach.

Smith offers a quote in another of his books, The Tactical Guide to Women, “Look for the red flags early in the relationship. If anything pops up early on, don’t let that slide. Most people are on their best behavior in the beginning. They hide it well until around the six-month mark. For example, if she gets drunk and is screaming at you for no reason within the first month, run as fast as you can. Don’t let something like that slide. There are underlying issues there.” This doesn’t mean that they are a bad person or unworthy of love or anything like that. But drinking and yelling is a sign that such a person might not be ideal for a long-term relationship commitment.

What about beneficial traits, or so-called “green flags?”

Smith suggests seeking clarity, maturity, and stability in a potential mate.

Anybody can communicate well when they and the relationship are at their best. Clarity, though, encompasses reliable communication and the ability to communicate during stormy periods. If a partner’s skills are unreliable, they may revert to more primitive means of self-expression, such as passive-aggressiveness and outbursts. Good relationships require that both partners express themselves constructively, especially during times of stress.

Relatedly, inquisitiveness is an important skill. It cuts through ambiguities and insecurities. Within a relationship, if one person behaves in an insensitive manner, a sign of inquisitiveness would be if his or her partner, rather than expressing anger, calmly asks why and listens. This can open the path to communication and understanding, rather than mutually escalating hostilities. As Smith puts it, “The inquisitive person places facts and reality above emotion. Emotions still exist, they’re just not in the driver’s seat.” Inquisitiveness works when both individuals try to understand the other person, rather than make assumptions based on limited information.

Emotional maturity is another green flag. Some signs of this skill: She can calm herself when she’s sad or angry, she accepts reality, she keeps commitments, she takes care of relationships and doesn’t burn bridges, she bases important decisions on values rather than impulse, and she possesses the emotional resources to function well among coworkers, family, and friends.

Stability, another positive quality, indicates that a woman handles her personal challenges and cares for herself so that her life (and yours) isn’t a series of crises. As Smith puts it, a woman “who is unwilling to strive for her best state of mental health is unlikely to succeed in relationships.”

Many men devote monumental effort to educational attainment, career striving, and occupational success. It would be wise to expend no less effort on identifying a compatible partner.

Instead of seeing a potential romantic partner as someone who can support your career ambitions, you could also view your career as something that can improve life for you, your future spouse, and your family.

In The Seasons of a Man’s Life, Daniel J. Levinson describes “a unique relationship that ordinarily includes loving, romantic, tender, and sexual feelings, but it goes beyond this.” He describes the “special woman,” who in turn experiences her partner as a “special man.” The special woman is someone who “generates and supports his heroic strivings” and “joins him on his journey” to shape and live out his ambitions, where “his aspirations can be imagined and his hopes nourished.”

In return, he supports the special woman’s hopes and dreams. “A couple can form a lasting relationship that furthers his development only if it also furthers hers…If in supporting his Dream she loses her own, then her development will suffer and both will later pay the price.”

And Levinson, too, notes that “occupation and marriage-family are usually the most central components” in a man’s life.

This perspective on relationships underscores the importance of mutual support and shared growth. The notion of the “special woman” and “special man” transcends the conventional understanding of romantic partnerships, emphasizing a deeper, more harmonious connection. This link is not solely about love or attraction or sex; it is about finding a partner who understands, encourages, and participates in your life journey. Such a relationship becomes a crucible for personal and professional development, where both individuals are not just companions but co-architects of a shared future.

https://www.robkhenderson.com/p/how-to-choose-a-romantic-partner

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #435 on: March 24, 2024, 11:48:00 PM »
Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder

The goals of this perspective are four-fold: 1) to advance the
novel hypothesis that brain AVP deficiency drives both social
interaction impairments and fluid imbalance in at least some
individuals with autism spectrum disorder (ASD); 2) to synthesize
emerging evidence consistent with this hypothesis; 3) to outline a
strategy for testing and confirming this hypothesis; and 4) to
propose a laboratory-based method for detecting AVP deficiency,
in order to identify autistic individuals who may be most likely to
benefit from AVP therapy.

A BRIEF HISTORY OF AVP’S PERIPHERAL AND CENTRAL

AVP is a nonapeptide initially studied as a classic hormone due to its release from the hypothalamic-pituitary-portal into peripheral circulation. The name AVP refers to the hormone’s role in increasing vascular resistance and regulating blood pressure (via AVP receptor 1A [AVPR1A]), whereas the name ADH refers to itsrole in regulating osmolality and renal water handling (via AVPR2).

Although hypothalamic and extra-hypothalamic AVP neurons were known to project throughout the brain, AVP’s names hindered the elucidation of its role in brain-related behavioral processes.
Decades would pass before neuroscientists identified AVP as a key regulator of mammalian social behavior (e.g., social recognition memory, pair-bond formation, paternal care), acting primarily through brain AVPR1A.
A role for the central AVP pathway in ASD was later hypothesized, as persistent social interaction difficulties are a core feature of ASD. Empirical research subsequently showed that both children with ASD and infants who later receive an ASD diagnosis have significantly lower cerebrospinal fluid (CSF) AVP concentrations compared to controls. (Notably, these studies found no group differences in CSF concentrations of oxytocin (OXT), a nearly structurally identical neuropeptide also involved in social functioning , demonstrating the specificity of these AVP findings.)
Finally, consistent with brain AVP deficiency, a pilot placebo-controlled trial recently reported that intranasal AVP treatment improves social abilities in children with ASD.
(3 pages)

https://med.stanford.edu/content/dam/sm/parkerlab/documents/da035ad7-7c80-41bd-a9a6-ee03a8bcc58d.pdf

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #436 on: March 27, 2024, 08:45:10 PM »
Altered Brain pH Linked to Cognitive Disorders  (not sure bout this one...)
(...)
Widespread Phenomenon: Significant changes in brain pH and lactate levels were observed in 30% of the animal models studied, indicating a common energy metabolism dysfunction across various neuropsychiatric conditions.
   
Link to Cognitive Impairment: Elevated lactate levels were predominantly associated with impaired working memory, highlighting a direct impact on cognitive function.
   
Potential for New Treatments: The identification of altered brain energy metabolism as a transdiagnostic endophenotype paves the way for innovative treatment approaches targeting shared metabolic dysfunctions.
(snip)
This study, encompassing 109 strains/conditions of mice, rats, and chicks, including animal models related to neuropsychiatric conditions, reveals that changes in brain pH and lactate levels are a common feature in a diverse range of animal models of disorders, including schizophrenia/developmental disorders, bipolar disorder, autism, as well as models of depression, epilepsy, and Alzheimer’s disease. This study’s significant insights include:
(snip)
“Future studies will center on uncovering treatment strategies that are effective across diverse animal models with brain pH changes. This could significantly contribute to developing tailored treatments for patient subgroups characterized by specific alterations in brain energy metabolism.”

In this paper, the mechanistic insights into the reduction in pH and the increase in lactate levels remain elusive. However, it is known that lactate production increases in response to neural hyperactivity to meet the energy demand, and the authors seem to think this might be the underlying reason.

https://neurosciencenews.com/brain-ph-cognitive-disorders-25813/


“Large-scale Animal Model Study Uncovers Altered Brain pH and Lactate Levels as a Transdiagnostic Endophenotype of Neuropsychiatric Disorders Involving Cognitive Impairment   (Life)

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #437 on: March 27, 2024, 08:55:25 PM »
(and on the next page, we see inflammation reqd to make memories, so above model asking wrong question?)

DNA Damage and Inflammation Key to Memory Formation
(...)
“But our findings suggest that inflammation in certain neurons in the brain’s hippocampal region is essential for making long-lasting memories.”

The hippocampus has long been known as the brain’s memory center. Dr. Radulovic and her colleagues found that a stimulus sets off a cycle of DNA damage and repair within certain hippocampal neurons that leads to stable memory assemblies—clusters of brain cells that represent our past experiences. Elizabeth Wood, a Ph.D. student, and Ana Cicvaric, a postdoc in the Radulovic lab, were the study’s first authors at Einstein. 

From Shocks to Stable Memories

The researchers discovered this memory-forming mechanism by giving mice brief, mild shocks sufficient to form a memory of the shock event (episodic memory). They then analyzed neurons in the hippocampal region and found that genes participating in an important inflammatory signaling pathway had been activated.

“We observed strong activation of genes involved in the Toll-Like Receptor 9 (TLR9) pathway,” said Dr. Radulovic, who is also director of the Psychiatry Research Institute at Montefiore Einstein (PRIME).

“This inflammatory pathway is best known for triggering immune responses by detecting small fragments of pathogen DNA. So at first we assumed the TLR9 pathway was activated because the mice had an infection. But looking more closely, we found, to our surprise, that TLR9 was activated only in clusters of hippocampal cells that showed DNA damage.”

Brain activity routinely induces small breaks in DNA that are repaired within minutes. But in this population of hippocampal neurons, the DNA damage appeared to be more substantial and sustained.

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Re: Human Stupidity (Human Mental Illness)
« Reply #438 on: March 28, 2024, 09:24:09 PM »
Great rant from someone in the third world , but raised here. So he cusses correctly.
https://indi.ca/a-future-without-planes-or-container-ships/

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #439 on: April 10, 2024, 01:02:26 AM »
Spooky films may actually aid your mental health.

Experts reveal the psychology of Hollywood horror
Although horror movies have traditionally been the subject of panic, experts say they can benefit the mind

(...)
Based on this evidence after the release of such famous horror flicks as "The Exorcist" and "Silent Night, Deadly Night," it would seem that horror movies are bad for people's health. Yet literal hysterical reactions notwithstanding, experts actually argue exactly the opposite: The venerable Halloween tradition of watching scary movies is actually beneficial for your mental health.

Related
The psychology of gore: Why do we like graphic blood and guts in our entertainment?

"There is some research on this in psychology, but I think what's basically been found is that there's a benefit to rehearsing fears in your mind," Matthew Strohl, an assistant philosophy professor at University of Montana and author of "Why It's OK to Love Bad Movies," told Salon. "You can gain a sense of distance from them. You can gain a sense of control over them through this sort of exposure therapy, as it were, by repeatedly putting yourself in a position where you have to engage with them. But because it's in a fictional artistic context, you have a sense of control."

Frank T. McAndrew, Ph.D. — the Cornelia H. Dudley Professor of Psychology at Knox College, who has studied how places can "creep" people out — elaborated on the science behind how horror movies are in many ways ideal as a specific vehicle for meeting this need to be scared.

"That is kind of wired into us," McAndrew pointed out. "We like stories. We like to learn through the experience of other people. We learn valuable lessons that might be kind of costly to learn on our own. So we gravitate to horror movies and horror experiences because by watching other people deal with scary things, we can mentally practice strategies that will make us better prepared for dealing with that ourselves in the future. If I watch what happens to people who are being pursued by a serial killer and the mistakes they make, maybe I can avoid those myself in the future."

McAndrew added that while people may not do this consciously, this is an impulse derived from how "for our ancestors, it paid off to learn from the experience of others."

That said, subconsciously preparing for potential life-and-death situations is not the only reason why people enjoy horror movies. For others there is also "that emotional bump that we get. We get that adrenaline rush. We get the excitement. We like any exciting movie that's got a lot of action in it. We get our hearts racing and we have this emotional experience that we find to be pleasurable. Now some people find it to be more pleasurable than other people do, but nevertheless, we're not doing it just because we're going to learn something. You come out of there with the same feeling we have on amusement park rides."
(more)

https://www.salon.com/2023/10/14/spooky-films-may-actually-aid-your-mental-health-experts-reveal-the-psychology-of-hollywood-horror/

(Silent Night, how quaint. Should have brought up Evil Dead and Hostel, but oh well.
here is the link to the movie the authors original story was from about the Overlook horror flick festival. Oh , and don't forget to watch Exorcist 3, actors lab.)

« Last Edit: April 10, 2024, 01:08:11 AM by morganism »

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #440 on: April 17, 2024, 08:20:40 PM »
Psychiatric risks for worsened mental health after psychedelic use

Background:
Resurgent psychedelic research has largely supported the safety and efficacy of psychedelic therapy for the treatment of various psychiatric disorders. As psychedelic use and therapy increase in prevalence, so does the importance of understanding associated risks. Cases of prolonged negative psychological responses to psychedelic therapy seem to be rare; however, studies are limited by biases and small sample sizes. The current analytical approach was motivated by the question of whether rare but significant adverse effects have been under-sampled in psychedelic research studies.
Methods:
A “bottom margin analysis” approach was taken to focus on negative responders to psychedelic use in a pool of naturalistic, observational prospective studies (N = 807). We define “negative response” by a clinically meaningful decline in a generic index of mental health, that is, one standard error from the mean decrease in psychological well-being 4 weeks post-psychedelic use (vs pre-use baseline). We then assessed whether a history of diagnosed mental illness can predict negative responses.
Results:
We find that 16% of the cohort falls into the “negative responder” subset. Parsing the sample by self-reported history of psychiatric diagnoses, results revealed a disproportionate prevalence of negative responses among those reporting a prior personality disorder diagnosis (31%). One multivariate regression model indicated a greater than four-fold elevated risk of adverse psychological responses to psychedelics in the personality disorder subsample (b = 1.425, p < 0.05).

Conclusion:
We infer that the presence of a personality disorder may represent an elevated risk for psychedelic use and hypothesize that the importance of psychological support and good therapeutic alliance may be increased in this population.

https://journals.sagepub.com/doi/10.1177/02698811241232548

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #441 on: April 17, 2024, 08:47:01 PM »
Embezzlers are Nice People

We spend a lot of time suing embezzlers. All over the world. Week in and week out. Big embezzlers, small embezzlers, smart embezzlers and very smart embezzlers…

That’s right, no dumb embezzlers because almost all the embezzlers we encounter are smart. Some are very smart. Some are brilliant.

And, almost always, most would have made more money and had a more profitable career if they had simply stopped stealing and starting working honestly.

I mean, figure it out. An embezzler has to not only do his or her job well so that no one is looking over his or her shoulder but has to do their job so well that they can steal for months or years and it won’t show up. They have to be charismatic and knowledgeable enough so that no one bothers to double check their work. They have to be very steady in their work so that it cannot be reviewed because they are on vacation or ill…in short, they have to be great employees. And either so boring that all ignore their existence or so well liked that no one would question their character. Most choose the latter mode since it also allows access to more accounts and financial secrets.

And when embezzlers run entire companies, they have to create a bottom line successful enough for long enough that investors and business colleagues respect and trust them after review of the books…at least for a time.

Took me a long time to figure that out…for the first few years of practice, I found it incredible that such brilliant and attractive people would be dumb enough to risk it all for the relatively paltry gains that embezzlement can earn. I kept looking to see the underlying motivations since, I figured, I could better advise clients what to look out for if I could figure out precisely what makes an embezzler embezzle.

Now I know.

They embezzle because they like it. They like the rush. They need money now, not in five years. They like being smarter than the drudges they figure are around them. And they embezzle, I am convinced, because they want to get caught sooner or later and that pattern is usually repeated over and over.

Take one of my favorite embezzlers, a guy who once owned the famous Flamingo Hotel in California until his world crumbled around him during a case our client brought against him in the late 1970’s. I had represented a minority shareholder in the venture and after perhaps a year of very aggressive litigation, Eddie Chan (not his real name) called it quits, transferred the shell of a company that was left to my client along with most of the rest of his assets, settled for a suspended sentence with the district attorney (to my fury) and then called me to invite me to lunch.

I had only been practicing for five years at the time and was unused to the foibles of opposing parties. I was nonplussed and immediately called his counsel to ask if that would be OK…as required by the Code of Ethics.

“Sure,” the relatively famous criminal defense attorney chirped, “and tell him to pay my bill while you’re at it.”

So there I was two days later with Eddie at his favorite Italian restaurant, Orsi, watching him fiddle with his fettuccini, his hands nervously twitching every so often, but immaculately dressed in a conservative business suit, expensive cufflinks and watch, the picture of a successful and conservative business man.

He had greeted me in a rather distracted manner, looking about the room, but friendly enough. Since I had been instrumental in destroying his economic well-being, and since he knew I had been demanding his incarceration for his embezzlement with the district attorney, I wondered why we were having this lunch. Cautious, I figured I’d let him tell me. And, in turn, I’d try to figure out what made him tick.

The waiters all knew him. He was a regular and his waistline showed it. Friendly but not effusive, soft-spoken and understated, he appeared now as he had been throughout the trial…a typical intelligent businessman slightly shocked that people were upset with him, but just maybe a hint of irony somehow mixed into his replies. On the stand he had been asked what he had done with the money.

“Spent it. I have none left. If I did, perhaps I would pay it back.”

“On what did you spend it? Are those assets in the United States at this time?"

He had stared at me for a moment, knowing I was looking for assets to attach, then suddenly smiled sadly. “I spent it on sweet, stupid things that make life an appropriate journey. Little things with some elegance attached. Things only worth buying because they have little value in the long run. Like life, itself.”

There was some laughter in the court room but my client had begun to mutter darkly at my side, furious that these “little things” had bankrupted the hotel. As I sat there in that elegant restaurant, I decided that he had, for once, been telling the truth.
(more)

https://www.stimmel-law.com/en/articles/story-1-embezzlers-are-nice-people

CalamityCountdown

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Re: Human Stupidity (Human Mental Illness)
« Reply #442 on: April 23, 2024, 07:43:19 PM »
I have to think that building a massive new development in the Arizona desert qualifies for an entry in this "stupidity" thread.
"Encompassing nearly 37,000 acres in the Phoenix West Valley, one of the nation’s fastest-growing metro regions, Teravalis is anticipated to become one of the leading master planned communities in the country, with 100,000 homes, 300,000 residents and 55 million square feet of commercial development."
For reference, the current Arizona drought is approaching 15 years in length and has surpassed the worst drought in more than 110 years of official record keeping. Beyond the written record, tree ring research reveals that 20 to 30 year droughts have occurred several times over the past 1,000 years in the major watersheds serving the city of Phoenix and surrounding municipalities.

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #443 on: April 26, 2024, 10:30:58 PM »
How I Rewired My Brain to Become Fluent in Math

(...)
With my poor understanding of even the simplest math, my post-Army retraining efforts began with not-for-credit remedial algebra and trigonometry. This was way below mathematical ground zero for most college students. Trying to reprogram my brain sometimes seemed like a ridiculous idea—especially when I looked at the fresh young faces of my younger classmates and realized that many of them had already dropped their hard math and science classes—and here I was heading right for them. But in my case, from my experience becoming fluent in Russian as an adult, I suspected—or maybe I just hoped—that there might be aspects to language learning that I might apply to learning in math and science.

What I had done in learning Russian was to emphasize not just understanding of the language, but fluency. Fluency of something whole like a language requires a kind of familiarity that only repeated and varied interaction with the parts can develop. Where my language classmates had often been content to concentrate on simply understanding Russian they heard or read, I instead tried to gain an internalized, deep-rooted fluency with the words and language structure. I wouldn’t just be satisfied to know that понимать meant “to understand.” I’d practice with the verb—putting it through its paces by conjugating it repeatedly with all sorts of tenses, and then moving on to putting it into sentences, and then finally to understanding not only when to use this form of the verb, but also when not to use it. I practiced recalling all these aspects and variations quickly. After all, through practice, you can understand and translate dozens—even thousands— of words in another language. But if you aren’t fluent, when someone throws a bunch of words at you quickly, as with normal speaking (which always sounds horrifically fast when you’re learning a new language), you have no idea what they’re actually saying, even though technically you understand all the component words and structure. And you certainly can’t speak quickly enough yourself for native speakers to find it enjoyable to listen to you.

This approach—which focused on fluency instead of simple understanding—put me at the top of the class. And I didn’t realize it then, but this approach to learning language had given me an intuitive understanding of a fundamental core of learning and the development of expertise—chunking.

Chunking was originally conceptualized in the groundbreaking work of Herbert Simon in his analysis of chess—chunks were envisioned as the varying neural counterparts of different chess patterns. Gradually, neuroscientists came to realize that experts such as chess grand masters are experts because they have stored thousands of chunks of knowledge about their area of expertise in their long-term memory. Chess masters, for example, can recall tens of thousands of different chess patterns. Whatever the discipline, experts can call up to consciousness one or several of these well-knit-together, chunked neural subroutines to analyze and react to a new learning situation. This level of true understanding, and ability to use that understanding in new situations, comes only with the kind of rigor and familiarity that repetition, memorization, and practice can foster.

As studies of chess masters, emergency room physicians, and fighter pilots have shown, in times of critical stress, conscious analysis of a situation is replaced by quick, subconscious processing as these experts rapidly draw on their deeply ingrained repertoire of neural subroutines—chunks. At some point, self-consciously “understanding” why you do what you do just slows you down and interrupts flow, resulting in worse decisions.
(more)

https://nautil.us/how-i-rewired-my-brain-to-become-fluent-in-math-235085/

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #444 on: April 29, 2024, 09:52:54 PM »
Physical Fitness and Risk of Mental Disorders in Children and Adolescents

Question  Is physical fitness associated with long-term risks of mental disorders in children and adolescents?

Findings  This nationwide cohort study, encompassing 1.9 million participants in Taiwan, revealed that children and adolescents in better-performing fitness quantiles exhibited lower cumulative incidences of anxiety disorders, depressive disorders, and attention-deficit/hyperactivity disorder. Notably, enhanced cardiorespiratory fitness, muscular endurance, and muscular power were independently associated with reduced mental disorder incidences in this demographic, even after accounting for confounding factors.

Meaning  These findings suggest the potential of cardiorespiratory and muscular fitness as protective factors in mitigating the onset of mental disorders among children and adolescents.
Abstract

Importance  With the rising prevalence of mental disorders among children and adolescents, identifying modifiable associations is critical.

Objective  To examine the association between physical fitness and mental disorder risks.

Design, Setting, and Participants  This nationwide cohort study used data from the Taiwan National Student Fitness Tests and National Health Insurance Research Databases from January 1, 2009 to December 31, 2019. Participants were divided into 2 cohorts targeting anxiety and depression (1 996 633 participants) and attention-deficit/hyperactivity disorder (ADHD; 1 920 596 participants). Participants were aged 10 to 11 years at study entry and followed up for at least 3 years, had a nearly equal gender distribution, and an average follow-up of 6 years. Data were analyzed from October 2022 to February 2024.

Exposures  Assessments of physical fitness included cardiorespiratory fitness (CF), muscular endurance (ME), muscular power (MP), and flexibility, measured through an 800-m run time, bent-leg curl-ups, standing broad jump, and sit-and-reach test, respectively.

(snip)
Conclusions and Relevance  This study highlights the potential protective role of cardiorespiratory fitness, muscular endurance, and muscular power in preventing the onset of mental disorders. It warrants further investigation of the effectiveness of physical fitness programs as a preventive measure for mental disorders among children and adolescents.

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2818132

morganism

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Re: Human Stupidity (Human Mental Illness)
« Reply #445 on: May 06, 2024, 03:14:08 AM »
Who believes the most "taboo" conspiracy theories? It might not be who you think
White men with graduate degrees, a new study finds, are highly likely to hold especially noxious beliefs

https://www.salon.com/2024/05/05/believes-the-most-taboo-conspiracy-theories-it-might-not-be-you-think/

Ranman99

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Re: Human Stupidity (Human Mental Illness)
« Reply #446 on: May 06, 2024, 12:31:41 PM »
Sure, but one thing I learned at a young age around the MK-Ultra expose is that when the CIA admits to something, the truth is much, much worse. So once we equate the title conspiracy theorist with "nut job", then a big newspeak brick is locked into place! Sometimes if it looks like a turd and it smells like a turd it ain't an Oh Henry!!!
😎

Neven

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Re: Human Stupidity (Human Mental Illness)
« Reply #447 on: May 06, 2024, 01:20:26 PM »
Coincidence theorists suffer from the same mental deficiencies as conspiracy theorists. Both are relatively easy to manipulate, but given that traditionally, there are a lot more coincidence theorists, the repercussions on society and the environment are much larger.
The enemy is within
Don't confuse me with him

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zenith

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Re: Human Stupidity (Human Mental Illness)
« Reply #448 on: May 06, 2024, 05:52:34 PM »
it's hilarious that a term coined by the cia, conspiracy theorist, is attributed to those that are derogatorily assigned as mentally ill or easily manipulated. bring on the magic bullets.

I'm not a conspiracy theorist - I'm a conspiracy analyst - Gore Vidal

let's talk about the really intelligent people with PhD's doing important scientific research.

My dream died, and now I'm here


it's just a coincidence that money has destroyed science just like politics.  :-[

Where is reality? Can you show it to me? - Heinz von Foerster

zenith

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Re: Human Stupidity (Human Mental Illness)
« Reply #449 on: May 06, 2024, 06:15:06 PM »
long live the highly intelligent an unmanipulable people! long live scientism!

economics is a science too! don't listen to the icky mentally ill dissenters, conspiracy theorists! listen to paul krugman.

The Lost Science of Money: The Mythology of Money, The Story of Power - Stephen A. Zarlenga
https://www.goodreads.com/en/book/show/1992942

these two are stupid, easily manipulated, mentally ill conspiracy theorists! yuck.

Economic Update: The U.S. Economy As An Apartheid System


this guy too, they're everywhere! do not listen to these rejects.

Debunking Economics: The Naked Emperor Dethroned? - Steve Keen
https://www.goodreads.com/book/show/10303367-debunking-economics
Where is reality? Can you show it to me? - Heinz von Foerster