Did Viruses Create the Nucleus? The Answer May Be Near.https://www.quantamagazine.org/did-viruses-create-the-nucleus-the-answer-may-be-near-20201125/Scientists generally think eukaryotes first came on the scene between 2.5 billion and 1.5 billion years ago, when evidence suggests that a bacterium took up residence inside a different kind of prokaryote, an archaeon, and became its mitochondrion. But a deeper mystery surrounds the emergence of the nucleus; no one even knows whether that ancient archaeon was already a kind of proto-eukaryote with a nucleus, or whether the nucleus came later.
Any origin story for the eukaryotic nucleus needs to explain several of its features. There’s the nature of the structure, for starters: its nested inner and outer membranes, and the pores that connect its interior to the rest of the cell. There’s also the curious way it compartmentalizes the expression of genes within itself but leaves the construction of proteins outside. And a truly persuasive origin story must also explain why the nucleus exists at all — what evolutionary pressures pushed those ancient cells to wall up their genomes.
... “What we [eukaryotes] are is a classic case of what they call emergent complexity,” explained Philip Bell, the head of research for the yeast biotechnology company MicroBioGen. Bell proposed a viral origin for the eukaryotic nucleus back in 2001 and refreshed the theory in September. “It’s three organisms that came together to make a new community, which eventually integrated to such an extent that it became, effectively, a new life-form.” ... “Five minutes of looking and I go, ‘Jeez, if it’s an endosymbiont, it’s not a bacterial one,’” he recalled. There were just too many differences between bacterial and eukaryotic genomes, he felt, like the fact that eukaryotes have linear chromosomes while bacteria tend to have circular ones.

Bell believes an ancient giant virus infected an archaeon and set up a viral factory but didn’t kill its host cell. Instead, the structure managed to stick around. “And then the virus, which is a gene thief, stole the genes from the archaea and completely destroyed its genome,” he explained. That’s a common theme with viruses, especially giant ones — they take genes from their hosts, which makes them less dependent on their hosts. That might even help explain why so many mitochondrial genes have moved to the nucleus: “Over the years it has been stealing the genes from the mitochondria and starting to control it as well.”
So in a way, “the virus just wears the archaeon’s cell as a cloak,” Bell said.
And if that model is right, he pointed out, “you could say at the heart of every human cell is a virus.”------------------------------------------
... that may explain why Agent Smith had that heart-to-heart talk with Morpheus ...------------------------------------------
Might also explain panspermia ...
Spread viruses across the galaxy